P2X7 Receptor and Extracellular Vesicle Release

被引：6
作者：
Golia, Maria Teresa [1 ]
Gabrielli, Martina [1 ]
Verderio, Claudia [1 ]
机构：
[1] Natl Res Council Italy, Inst Neurosci, Via Raoul Follereau 3, I-20854 Vedano Al Lambro, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 12期
关键词：
P2X(7) receptor; extracellular vesicles; inflammation; neurodegeneration; BRILLIANT BLUE G; P2X7; RECEPTOR; INFLAMMASOME ACTIVATION; PURINERGIC RECEPTOR; ADP-RIBOSYLATION; CELL BIOLOGY; ATP; MICROVESICLES; SECRETION; MACROPHAGES;
D O I：
10.3390/ijms24129805
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Extensive evidence indicates that the activation of the P2X(7) receptor (P2X(7)R), an ATP-gated ion channel highly expressed in immune and brain cells, is strictly associated with the release of extracellular vesicles. Through this process, P2X(7)R-expressing cells regulate non-classical protein secretion and transfer bioactive components to other cells, including misfolded proteins, participating in inflammatory and neurodegenerative diseases. In this review, we summarize and discuss the studies addressing the impact of P2X(7)R activation on extracellular vesicle release and their activities.
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页数：13
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