Association of coexistence of frailty and depressive symptoms with mortality in community-dwelling older adults: Kashiwa Cohort Study

被引:4
作者
Hamada, Shota [1 ,2 ,3 ]
Sasaki, Yui [1 ,4 ]
Son, Bo-Kyung [5 ,6 ]
Tanaka, Tomoki [5 ]
Lyu, Weida [5 ]
Tsuchiya-Ito, Rumiko [1 ]
Kitamura, Satomi [1 ]
Dregan, Alex [7 ]
Hotopf, Matthew [7 ]
Iwagami, Masao [2 ]
Iijima, Katsuya [5 ,6 ]
机构
[1] Assoc Hlth Econ Res & Social Insurance & Welf, Inst Hlth Econ & Policy, Res Dept, Tokyu Toranomon Bldg,1-21-19 Toranomon,Minato Ku, Tokyo 1050001, Japan
[2] Univ Tsukuba, Inst Med, Dept Hlth Serv Res, Tsukuba, Japan
[3] Univ Tokyo, Grad Sch Med, Dept Home Care Med, Tokyo, Japan
[4] Assoc Hlth Econ Res & Social Insurance & Welf, Inst Hlth Econ & Policy, Policy Promot Dept, Tokyo, Japan
[5] Univ Tokyo, Inst Gerontol, Tokyo, Japan
[6] Univ Tokyo, Inst Future Initiat, Tokyo, Japan
[7] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England
关键词
Depression; Depressive symptoms; Frailty; Mortality; SCALE; RISK; LIFE; CARE;
D O I
10.1016/j.archger.2023.105322
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objectives: This study aimed to determine the longitudinal associations of the coexistence of frailty and depressive symptoms with mortality among older adults. Methods: The study participants were community-dwelling older adults aged >= 65 years who participated in the baseline survey of the Kashiwa Cohort Study in Japan in 2012. We used Fried's frailty phenotype criteria to classify participants as non-frail (score = 0), pre-frail (1 or 2), or frail (>= 3). Depressive symptoms were assessed using the GDS-15 (>= 6 points). Cox proportional hazards models were used to evaluate the association of cooccurring frailty and depressive symptoms with all-cause mortality, after adjusting for sociodemographic and clinical characteristics. Results: The study included 1920 participants, including 810 non-frail, 921 pre-frail, and 189 frail older adults, of which 9.0 %, 15.7 %, and 36.0 %, respectively, had depressive symptoms. Ninety-one (4.7 %) participants died during the average follow-up period of 4.8 years. Compared with non-frail participants without depressive symptoms, frail participants had greater adjusted hazard ratios for mortality: 2.47 (95 % CI, 1.16 to 5.25) for frail participants without depressive symptoms and 4.34 (95 % CI, 1.95 to 9.65) for frail participants with depressive symptoms. However, no statistically significant associations were observed in non-frail or pre-frail participants irrespective of depressive symptoms. Conclusion: Frail older adults with depressive symptoms have a substantially greater risk of mortality. Screening for depressive symptoms and frailty in older adults should be incorporated into health checkups and clinical practice to identify high-risk populations.
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页数:6
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