Pestalotiopols E-J, Six New Polyketide Derivatives from a Marine Derived Fungus Pestalotiopsis sp. SWMU-WZ04-1

被引：0

作者：

Jiang, Liyuan ^{[1
]}

Teng, Baorui ^{[1
]}

Zhang, Mengyu ^{[1
]}

Chen, Siwei ^{[1
]}

Zhang, Dan ^{[1
]}

Zhai, Longfei ^{[2
]}

Lin, Jiafu ^{[3
]}

Lei, Hui ^{[1
]}

机构：

[1] Southwest Med Univ, Sch Pharm, Luzhou 646000, Peoples R China

[2] Chengdu Univ, Sichuan Ind Inst Antibiot, Antibiot Res & Reevaluat Key Lab Sichuan Prov, Chengdu 610106, Peoples R China

[3] Chengdu Univ, Sch Pharm, Chengdu 610106, Peoples R China

来源：

MARINE DRUGS | 2024年 / 22卷 / 01期

关键词：

Pestalotiopsis sp; polyketide; sponge-derived fungus; antibacterial activity; cytotoxicity; ABSOLUTE-CONFIGURATION; MOSHERS METHOD; NMR; METABOLITES; ANTIBACTERIAL; ASSIGNMENT;

D O I：

10.3390/md22010015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical epigenetic cultivation of the sponge-derived fungus Pestalotiopsis sp. SWMU-WZ04-1 contributed to the identification of twelve polyketide derivatives, including six new pestalotiopols E-J (1-6) and six known analogues (7-12). Their gross structures were deduced from 1D/2D NMR and HRESIMS spectroscopic data, and their absolute configurations were further established by circular dichroism (CD) Cotton effects and the modified Mosher's method. In the bioassay, the cytotoxic and antibacterial activities of all compounds were evaluated. Chlorinated benzophenone derivatives 7 and 8 exhibited inhibitory effects on Staphylococcus aureus and Bacillus subtilis, with MIC values varying from 3.0 to 50 mu g/mL. In addition, these two compounds were cytotoxic to four types of human cancer cells, with IC50 values of 16.2 similar to 83.6 mu M. The result showed that compound 7 had the probability of being developed into a lead drug with antibacterial ability.

引用

页数：11