Itching in Atopic Dermatitis: Patient- and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany

被引：19

作者：

Weisshaar, Elke ^{[1
]}

Bentz, Philipp ^{[1
]}

Apfelbacher, Christian ^{[2
,3
]}

Haufe, Eva ^{[4
,5
]}

Heinrich, Luise ^{[4
,5
]}

Heratizadeh, Annice ^{[6
]}

Abraham, Susanne ^{[7
]}

Harder, Inken ^{[8
]}

Kleinheinz, Andreas ^{[9
]}

Wollenberg, Andreas ^{[10
]}

Schaekel, Knut ^{[11
]}

Wiemers, Franca ^{[12
]}

Ertner, Julia ^{[13
]}

Augustin, Matthias ^{[14
]}

Wildberger, Julia ^{[15
]}

von Kiedrowski, Ralph ^{[16
,17
]}

Worm, Margitta ^{[18
]}

Zink, Alexander ^{[19
]}

Effendy, Isaak ^{[20
]}

Asmussen, Andrea ^{[21
]}

Pawlak, Mario ^{[22
]}

Sticherling, Michael ^{[23
]}

Hilgers, Melanie ^{[24
,25
]}

Handrick, Christiane ^{[26
]}

Quist, Sven ^{[27
]}

Schwarz, Beate ^{[28
]}

Bell, Magnus ^{[29
]}

Staubach-Renz, Petra ^{[30
]}

Hong-Weldemann, Sung-Hei ^{[31
]}

Homey, Bernhard ^{[32
]}

Bruecher, Jens-Joachim ^{[33
]}

Weidinger, Stephan ^{[8
]}

Werfel, Thomas ^{[6
]}

Schmitt, Jochen ^{[4
,5
]}

机构：

[1] Heidelberg Univ, Dept Dermatol, Occupat Dermatol, DE-69115 Heidelberg, Germany

[2] Otto von Guericke Univ, Inst Social Med & Hlth Syst Res, Magdeburg, Germany

[3] Univ Regensburg, Inst Epidemiol & Prevent Med Med Sociol, Regensburg, Germany

[4] Tech Univ Dresden, Univ Hosp, Ctr Evidence Based Healthcare, Dresden, Germany

[5] Tech Univ Dresden, Med Fac Carl Gustav Carus, Dresden, Germany

[6] Hannover Med Sch, Dept Dermatol & Allergy, Div Immunodermatol & Allergy Res, Hannover, Germany

[7] Tech Univ Dresden, Univ Allergy Ctr, Med Fac Carl Gustav Carus, Dept Dermatol, Dresden, Germany

[8] Univ Hosp Schleswig Holstein, Ctr Inflammatory Skin Dis, Dept Dermatol & Allergy, Campus Kiel, Kiel, Germany

[9] Elbe Klinikum Buxtehude, Clin Dermatol, Buxtehude, Germany

[10] Ludwig Maximilians Univ Munchen, Clin & Outpatient Clin Dermatol & Allergy, Munich, Germany

[11] Heidelberg Univ, Dept Dermatol, Heidelberg, Germany

[12] Practice Dr Med Franca Wiemers, Leipzig, Germany

[13] Practice Dr Med Konstantin Ertner, Nurnberg, Germany

[14] Univ Med Ctr Hamburg Eppendorf, Inst Hlth Serv Res Dermatol, Hamburg, Germany

[15] Practice Dr Med Julia Wildberger, Hautmed, Bad Soden, Germany

[16] Focus Practice Chron Inflammatory Dermatoses Skin, Selters Westerwald, Germany

[17] Study Ctr CMS3 Co Med Study & Serv, Selters Westerwald, Germany

[18] Charite, Dept Dermatol Allergy & Venereol, Berlin, Germany

[19] Tech Univ Munich, Sch Med, Dept Dermatol & Allergy, Munich, Germany

[20] Bielefeld Univ, Dept Dermatol, OWL Univ Hosp, Campus Clin Bielefeld, Bielefeld, Germany

[21] Dermatol Lesum, Practice Dr Med Andrea Asmussen, Bremen, Germany

[22] Practice Dr Med Anika Hunermund & Mario Pawlak, Heiligenstadt, Germany

[23] Univ Erlangen Nurnberg, German Ctr Immunotherapy, Dept Dermatol, Erlangen, Germany

[24] Univ Hosp Aachen, Clin Dermatol, Aachen, Germany

[25] Univ Hosp Aachen, Clin Allergy, Aachen, Germany

[26] Practice Dr Med Christiane Handrick, Berlin, Germany

[27] Helix Med Excellence Ctr, Dermatol Clin, Mainz, Germany

[28] Practice Dr Med Beate Schwarz, Langenau, Germany

[29] Practice Dr Med Magnus Bell, Andernach, Germany

[30] Univ Hosp, Clin Dermatol, Mainz, Germany

[31] Practice Dr Med Sung Hei Hong Weldemann, Freiburg, Germany

[32] Univ Hosp Duesseldorf, Dept Dermatol & Allergol, Dusseldorf, Germany

[33] Hautambulatorium Magdeburg, Practice Dr Med Jens Joachim Brucher, Magdeburg, Germany

来源：

ACTA DERMATO-VENEREOLOGICA | 2023年 / 103卷

关键词：

EASI; POEM; pruritus; quality of life; registry; FATIGUE SEVERITY SCALE; TASK-FORCE; VALIDATION; ADULTS; RELIABILITY; LIFE;

D O I：

10.2340/actadv.v103.4426

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

TREATgermany is an investigator-initiated prospec-tive disease registry. It investigates physician-and patient-reported disease severity (Eczema Area and Severity Index (EASI), objective Scoring Atopic Der-matitis (oSCORAD), Investigator Global Assessment, Patient-Oriented Eczema Measure (POEM), Patient Global Assessment (PGA)), patient-reported symp-toms (itch, sleep loss, depressive symptoms), thera-py courses and dermatological quality of life (DLQI) in moderate-to-severe atopic dermatitis with SCORAD > 20. 1,134 atopic dermatitis patients (mean age 41.0 +/- 14.7 years, 42.5% females) were enrolled by 40 German recruiting sites (dermatological clinics and practices) between June 2016 and April 2021. The cur-rent analysis focuses on itch scores obtained with a numerical rating scale (NRS)) documented for the pre-vious 3 days prior to baseline visit. The results show that 97.2% (1,090 of 1,121) patients experienced itch. Itch severity correlated moderately with severity of atopic dermatitis oSCORAD (rho = 0.44 (0.39-0.48)) and EASI score (rho = 0.41 (0.36-0.46)). A strong cor-relation was found with self-reported disease severi-ty as PGA (rho = 0.68 (0.65-0.71)), POEM sum score (rho = 0.66 (0.63-0.69)) and dermatological quality of life impairment DLQI (rho = 0.61 (0.57-0.65)). Itch as a subjective complaint is more closely correlated with patient-reported outcomes than with objective assess-ments by the physician.

引用

页数：6

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