Itching in Atopic Dermatitis: Patient- and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany

被引：19

作者：

Weisshaar, Elke ^{[1
]}

Bentz, Philipp ^{[1
]}

Apfelbacher, Christian ^{[2
,3
]}

Haufe, Eva ^{[4
,5
]}

Heinrich, Luise ^{[4
,5
]}

Heratizadeh, Annice ^{[6
]}

Abraham, Susanne ^{[7
]}

Harder, Inken ^{[8
]}

Kleinheinz, Andreas ^{[9
]}

Wollenberg, Andreas ^{[10
]}

Schaekel, Knut ^{[11
]}

Wiemers, Franca ^{[12
]}

Ertner, Julia ^{[13
]}

Augustin, Matthias ^{[14
]}

Wildberger, Julia ^{[15
]}

von Kiedrowski, Ralph ^{[16
,17
]}

Worm, Margitta ^{[18
]}

Zink, Alexander ^{[19
]}

Effendy, Isaak ^{[20
]}

Asmussen, Andrea ^{[21
]}

Pawlak, Mario ^{[22
]}

Sticherling, Michael ^{[23
]}

Hilgers, Melanie ^{[24
,25
]}

Handrick, Christiane ^{[26
]}

Quist, Sven ^{[27
]}

Schwarz, Beate ^{[28
]}

Bell, Magnus ^{[29
]}

Staubach-Renz, Petra ^{[30
]}

Hong-Weldemann, Sung-Hei ^{[31
]}

Homey, Bernhard ^{[32
]}

Bruecher, Jens-Joachim ^{[33
]}

Weidinger, Stephan ^{[8
]}

Werfel, Thomas ^{[6
]}

Schmitt, Jochen ^{[4
,5
]}

机构：

[1] Heidelberg Univ, Dept Dermatol, Occupat Dermatol, DE-69115 Heidelberg, Germany

[2] Otto von Guericke Univ, Inst Social Med & Hlth Syst Res, Magdeburg, Germany

[3] Univ Regensburg, Inst Epidemiol & Prevent Med Med Sociol, Regensburg, Germany

[4] Tech Univ Dresden, Univ Hosp, Ctr Evidence Based Healthcare, Dresden, Germany

[5] Tech Univ Dresden, Med Fac Carl Gustav Carus, Dresden, Germany

[6] Hannover Med Sch, Dept Dermatol & Allergy, Div Immunodermatol & Allergy Res, Hannover, Germany

[7] Tech Univ Dresden, Univ Allergy Ctr, Med Fac Carl Gustav Carus, Dept Dermatol, Dresden, Germany

[8] Univ Hosp Schleswig Holstein, Ctr Inflammatory Skin Dis, Dept Dermatol & Allergy, Campus Kiel, Kiel, Germany

[9] Elbe Klinikum Buxtehude, Clin Dermatol, Buxtehude, Germany

[10] Ludwig Maximilians Univ Munchen, Clin & Outpatient Clin Dermatol & Allergy, Munich, Germany

[11] Heidelberg Univ, Dept Dermatol, Heidelberg, Germany

[12] Practice Dr Med Franca Wiemers, Leipzig, Germany

[13] Practice Dr Med Konstantin Ertner, Nurnberg, Germany

[14] Univ Med Ctr Hamburg Eppendorf, Inst Hlth Serv Res Dermatol, Hamburg, Germany

[15] Practice Dr Med Julia Wildberger, Hautmed, Bad Soden, Germany

[16] Focus Practice Chron Inflammatory Dermatoses Skin, Selters Westerwald, Germany

[17] Study Ctr CMS3 Co Med Study & Serv, Selters Westerwald, Germany

[18] Charite, Dept Dermatol Allergy & Venereol, Berlin, Germany

[19] Tech Univ Munich, Sch Med, Dept Dermatol & Allergy, Munich, Germany

[20] Bielefeld Univ, Dept Dermatol, OWL Univ Hosp, Campus Clin Bielefeld, Bielefeld, Germany

[21] Dermatol Lesum, Practice Dr Med Andrea Asmussen, Bremen, Germany

[22] Practice Dr Med Anika Hunermund & Mario Pawlak, Heiligenstadt, Germany

[23] Univ Erlangen Nurnberg, German Ctr Immunotherapy, Dept Dermatol, Erlangen, Germany

[24] Univ Hosp Aachen, Clin Dermatol, Aachen, Germany

[25] Univ Hosp Aachen, Clin Allergy, Aachen, Germany

[26] Practice Dr Med Christiane Handrick, Berlin, Germany

[27] Helix Med Excellence Ctr, Dermatol Clin, Mainz, Germany

[28] Practice Dr Med Beate Schwarz, Langenau, Germany

[29] Practice Dr Med Magnus Bell, Andernach, Germany

[30] Univ Hosp, Clin Dermatol, Mainz, Germany

[31] Practice Dr Med Sung Hei Hong Weldemann, Freiburg, Germany

[32] Univ Hosp Duesseldorf, Dept Dermatol & Allergol, Dusseldorf, Germany

[33] Hautambulatorium Magdeburg, Practice Dr Med Jens Joachim Brucher, Magdeburg, Germany

来源：

ACTA DERMATO-VENEREOLOGICA | 2023年 / 103卷

关键词：

EASI; POEM; pruritus; quality of life; registry; FATIGUE SEVERITY SCALE; TASK-FORCE; VALIDATION; ADULTS; RELIABILITY; LIFE;

D O I：

10.2340/actadv.v103.4426

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

TREATgermany is an investigator-initiated prospec-tive disease registry. It investigates physician-and patient-reported disease severity (Eczema Area and Severity Index (EASI), objective Scoring Atopic Der-matitis (oSCORAD), Investigator Global Assessment, Patient-Oriented Eczema Measure (POEM), Patient Global Assessment (PGA)), patient-reported symp-toms (itch, sleep loss, depressive symptoms), thera-py courses and dermatological quality of life (DLQI) in moderate-to-severe atopic dermatitis with SCORAD > 20. 1,134 atopic dermatitis patients (mean age 41.0 +/- 14.7 years, 42.5% females) were enrolled by 40 German recruiting sites (dermatological clinics and practices) between June 2016 and April 2021. The cur-rent analysis focuses on itch scores obtained with a numerical rating scale (NRS)) documented for the pre-vious 3 days prior to baseline visit. The results show that 97.2% (1,090 of 1,121) patients experienced itch. Itch severity correlated moderately with severity of atopic dermatitis oSCORAD (rho = 0.44 (0.39-0.48)) and EASI score (rho = 0.41 (0.36-0.46)). A strong cor-relation was found with self-reported disease severi-ty as PGA (rho = 0.68 (0.65-0.71)), POEM sum score (rho = 0.66 (0.63-0.69)) and dermatological quality of life impairment DLQI (rho = 0.61 (0.57-0.65)). Itch as a subjective complaint is more closely correlated with patient-reported outcomes than with objective assess-ments by the physician.

引用

页数：6

共 50 条

[1] Itching and treatments in atopic dermatitis (AD): results from the German AD registry TREATgermany
Weisshaar, Elke
Bentz, Philipp
Haufe, Eva
Heinrich, Luise
Apfelbacher, Christian
Heratizadeh, Annice
Abraham, Susanne
Harder, Inken
Kleinheinz, Andreas
Wollenberg, Andreas
Schaekel, Knut
Wiemers, Franca
Ertner, Konstantin
Augustin, Matthias
Wildberger, Julia
von Kiedrowski, Ralph
Worm, Margitta
Zink, Alexander
Effendy, Isaak
Asmussen, Andrea
Pawlak, Mario
Sticherling, Michael
Hilgers, Melanie
Handrick, Christiane
Quist, Sven
Schwarz, Beate
Bell, Magnus
Staubach-Renz, Petra
Hong-Weldemann, Su-Hei
Homey, Bernhard
Bruecher, Jens
Weidinger, Stephan
Werfel, Thomas
Schmitt, Jochen
BRITISH JOURNAL OF DERMATOLOGY, 2023, 188 (03) : 430 - 432
[2] Status report on the atopic dermatitis registry TREATgermany
Siegels, D.
Haufe, E.
Heinrich, L.
Werfel, T.
Weidinger, S.
Schmitt, J.
ALLERGOLOGIE, 2021, 44 (09) : 724 - 737
[3] Fatigue and Atopic Dermatitis: Results from the German Atopic Dermatitis Registery TREATgermany
Helmert, C.
Haufe, E.
Abraham, S.
Heratizadeh, A.
Harder, I
Kleinheinz, A.
Wollenberg, A.
Wiemers, F.
Weisshaar, E.
Augustin, M.
von Kiedrowski, R.
Wildberg, J.
Pawlak, M.
Hilgers, M.
Worm, M.
Schaekel, K.
Sticherling, M.
Effendy, I
Staubach-Renz, P.
Handrick, C.
Bell, M.
Asmussen, A.
Schwarz, B.
Werfel, T.
Weidinger, S.
Schmitt, J.
GESUNDHEITSWESEN, 2021, 83 (08/09) : 731 - 732
[4] Assessment of the Severity of Atopic Dermatitis by Physicians and Patients depending on Gender: Results from the German Atopic Dermatitis Registry TREATgermany
Heinrich, L.
Haufe, E.
Abraham, S.
Heratizadeh, A.
Harder, I
Kleinheinz, A.
Wollenberg, A.
Weisshaar, E.
Wiemers, F.
Ertner, K.
Schaekel, K.
Augustin, M.
Wildberger, J.
von Kiedrowski, R.
Zink, A.
Pawlak, M.
Worm, M.
Sticherling, M.
Effendy, I
Hilgers, M.
Quist, S.
Asmussen, A.
Handrick, C.
Bell, M.
Staubauch-Renz, P.
Schwarz, B.
Hong-Weldemann, S-H
Homey, B.
Werfel, T.
Weidinger, S.
Schmitt, J.
GESUNDHEITSWESEN, 2021, 83 (08/09) : 730 - 731
[5] Baseline characteristics of patients with Atopic Dermatitis observed in the German AD Registry TREATgermany
Weidinger, S.
Haufe, E.
Stoelzl, D.
Baurecht, H.
Abraham, S.
Harder, I.
Heratizadeh, A.
Bobylev, T.
Zink, A.
Weisshaar, E.
von Kiedrowski, R.
Wollenberg, A.
Worm, M.
Neubert, K.
Staubach-Renz, P.
Bieber, T.
Bell, M.
Werfel, T.
Schmitt, J.
EXPERIMENTAL DERMATOLOGY, 2018, 27 (03) : E44 - E44
[6] Atopic dermatitis and depressive symptoms. Results of the German national AD Registry TREATgermany
Helmert, C.
Haufe, E.
Heinrich, L.
Siegels, D.
Abraham, S.
Heratizadeh, A.
Harder, I.
Kleinheinz, A.
Wollenberg, A.
Wiemers, F.
Weisshaar, E.
Augustin, M.
von Kiedrowski, R.
Zink, A.
Pawlak, M.
Schakel, K.
Wildberger, J.
Weidinger, S.
Werfel, T.
Schmitt, J.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2022, 36 (04) : E279 - E282
[7] Patient- vs. provider-reported outcomes in a multidisciplinary atopic dermatitis clinic
Appiah, M. M.
Loop, L.
Villapando, N.
Kleinman, E.
Laborada, J.
Geng, B.
Eichenfield, L.
BRITISH JOURNAL OF DERMATOLOGY, 2022, 186 (04) : E165 - E166
[8] Patient-reported outcomes in atopic dermatitis and psoriasis
Secrest, A. M.
Gale, C. M.
Gardiner, A.
Hess, R.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2019, 139 (05) : S103 - S103
[9] Dietary modifications in atopic dermatitis: patient reported outcomes
Nosrati, A.
Afifi, L.
Danesh, M. J.
Lee, K.
Yan, D.
Ahn, R.
Liao, W.
EXPERIMENTAL DERMATOLOGY, 2016, 25 : 44 - 45
[10] Baseline characteristics and quality of life of patients with atopic dermatitis observed in the German AD registry TREATgermany
Weidinger, S.
Haufe, E.
Stoelzl, D.
Abraham, S.
Harder, I.
Heratizadeh, A.
Zink, A.
Weisshaar, E.
Bobylev, T.
Von Kiedrowski, R.
Worm, M.
Baron, J. M.
Bell, M.
Wollenberg, A.
Neubert, K.
Staubach-Renz, P.
Bieber, T.
Fell, I.
Beissert, S.
Werfel, T.
Schmitt, J.
BRITISH JOURNAL OF DERMATOLOGY, 2018, 179 (01) : E52 - E53

← 1 2 3 4 5 →