Available and novel plant-based carbon dots derived from Vaccaria Semen carbonisata alleviates liver fibrosis

被引：2

作者：

Zhao, Yafang ^{[1
]}

Dai, Ertong ^{[2
]}

Dong, Liyang ^{[1
]}

Yuan, Jinye ^{[1
]}

Zhao, Yusheng ^{[1
]}

Wu, Tong ^{[3
]}

Kong, Ruolan ^{[1
]}

Li, Menghan ^{[1
]}

Wang, Shuxian ^{[1
]}

Zhou, Long ^{[1
]}

Yang, Yingxin ^{[1
]}

Kong, Hui ^{[1
]}

Zhao, Yan ^{[1
]}

Qu, Huihua ^{[4
]}

机构：

[1] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing, Peoples R China

[2] Qingdao Eighth Peoples Hosp, Qingdao, Shandong, Peoples R China

[3] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China

[4] Beijing Univ Chinese Med, Ctr Sci Expt, Beijing, Peoples R China

来源：

FRONTIERS IN MOLECULAR BIOSCIENCES | 2023年 / 10卷

关键词：

carbon dots; Vaccaria Semen; antifibrotic; anti-inflammatory; antioxidant; INDUCED HEPATIC-FIBROSIS; NF-KAPPA-B; QUANTUM DOTS; OXIDATIVE STRESS; INFLAMMATION; NANOPARTICLES; ANTIOXIDANT; PATHWAY; RATS; MICE;

D O I：

10.3389/fmolb.2023.1282929

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Liver fibrosis represents an intermediate stage in the progression of liver disease, and as of now, there exists no established clinical therapy for effective antifibrotic treatment. Purpose: Our aim is to explore the impact of Carbon dots derived from Vaccaria Semen Carbonisata (VSC-CDs) on carbon tetrachloride-induced liver fibrosis in mice. Methods: VSC-CDs were synthesized employing a modified pyrolysis process. Comprehensive characterization was performed utilizing various techniques, including transmission electron microscopy (TEM), multiple spectroscopies, X-ray photoelectron spectroscopy (XPS), and high-performance liquid chromatography (HPLC). A hepatic fibrosis model induced by carbon tetrachloride was utilized to evaluate the anti-hepatic fibrosis effects of VSC-CDs. Results: VSC-CDs, exhibiting a quantum yield (QY) of approximately 2.08%, were nearly spherical with diameters ranging from 1.0 to 5.5 nm. The VSC-CDs prepared in this study featured a negative charge and abundant chemical functional groups. Furthermore, these particles demonstrated outstanding dispersibility in the aqueous phase and high biocompatibility. Moreover, VSC-CDs not only enhanced liver function and alleviated liver damage in pathomorphology but also mitigated the extent of liver fibrosis. Additionally, this study marks the inaugural demonstration of the pronounced activity of VSC-CDs in inhibiting inflammatory reactions, reducing oxidative damage, and modulating the TGF-beta/Smad signaling pathway. Conclusion: VSC-CDs exerted significant potential for application in nanodrugs aimed at treating liver fibrosis.

引用

页数：15

共 72 条

[71]

[赵亚芳 Zhao Yafang], 2021, [中草药, Chinese Traditional and Herbal Drugs], V52, P6825

[72] Carbon Dots from Paeoniae Radix Alba Carbonisata: Hepatoprotective Effect [J].

Zhao, Yusheng ;

Zhang, Yue ;

Kong, Hui ;

Zhang, Meiling ;

Cheng, Jinjun ;

Wu, Jiashu ;

Qu, Huihua ;

Zhao, Yan .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2020, 15 :9049-9059

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