In Search of the Holy Grail of Artificial Hearts: Are We There Yet?

被引：0
作者：
Volod, Oksana [1 ,4 ]
Colon, Modesto J. [2 ]
Arabia, Francisco A. [3 ]
机构：
[1] Cedars Sinai Med Ctr, Dept Pathol, Los Angeles, CA USA
[2] Univ Arizona, Coll Med, Dept Surg, Phoenix, AZ USA
[3] Univ Arizona, Coll Med, Dept Surg & Med, Adv Heart Program,Banner Hlth, Phoenix, AZ USA
[4] Cedars Sinai, Dept Pathol & Lab Med, 8700 Beverly Blvd,Room 4711, Los Angeles, CA 90048 USA
来源：
SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2024年 / 50卷 / 01期
关键词：
total artificial heart; history; anticoagulation; TRANSPLANTATION; BRIDGE; EXPERIENCE; ANTICOAGULATION; GIBBON; JOHN; H; FAILURE; END;
D O I：
10.1055/s-0043-1772456
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The total artificial heart (TAH) has a long and rich history, being the product of decades of innovation, hard work, and dedication. This review examines the history of the TAH, a device that has revolutionized the treatment of end-stage biventricular heart failure. It reviews the development of the device from early concepts to the current state-of-the-art device, the SynCardia TAH, which has been implanted in over 2,000 patients worldwide. The article also discusses the challenges and successes experienced by researchers, clinicians, and patients throughout the development of TAH devices. Our focus will also be on discussing the hemostatic alterations in patients implanted with TAH and anticoagulation strategies to decrease associated thromboembolic risks. The article concludes with a look at other novel TAH devices and the future of TAH as an increasingly viable treatment for end-stage heart failure.
引用
收藏
页码：104 / 114
页数：11
相关论文
共 50 条
  • [41] Point-of-care coagulation management algorithms during ECMO support: are we there yet?
    Boliger, Daniel
    Zenklusen, Urs
    Tanaka, Kenichi A.
    [J]. MINERVA ANESTESIOLOGICA, 2016, 82 (09) : 1000 - 1009
  • [42] The Post-Left Atrial Appendage Occlusion Antithrombotic Selection Conundrum Are We There Yet?
    Katapadi, Aashish
    Lakkireddy, Dhanunjaya
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2024, 84 (10) : 901 - 903
  • [43] Implantable Mechanical Circulatory Support: Demystifying Patients With Ventricular Assist Devices and Artificial Hearts
    Shah, Keyur B.
    Tang, Daniel G.
    Cooke, Richard H.
    Harton, Suzanne
    Flattery, Maureen
    Katlaps, Gundars J.
    Kasirajan, Vigneshwar
    Hess, Michael L.
    [J]. CLINICAL CARDIOLOGY, 2011, 34 (03) : 147 - 152
  • [44] Mechanistic biomarkers in acute liver injury: Are we there yet?
    Adebayo, Danielle
    Mookerjee, Rajeshwar P.
    Jalan, Rajiv
    [J]. JOURNAL OF HEPATOLOGY, 2012, 56 (05) : 1003 - 1005
  • [45] Are We There Yet? The American Automobile Past, Present, and Driverless
    Lucsko, David N.
    [J]. IEEE TECHNOLOGY AND SOCIETY MAGAZINE, 2020, 39 (02) : 78 - 79
  • [46] Population Testing for High Penetrance Genes: Are We There Yet?
    Wentzensen, Nicolas
    Berg, Christine D.
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2018, 110 (07): : 687 - 689
  • [47] OPINION Total artificial hearts: past, present, and future
    Cohn, William E.
    Timms, Daniel L.
    Frazier, O. H.
    [J]. NATURE REVIEWS CARDIOLOGY, 2015, 12 (10) : 609 - 617
  • [48] Balancing the ventricular outputs of pulsatile total artificial hearts
    Gulcher, Oskar J.
    Vis, Annemijn
    Peirlinck, Mathias
    Kluin, Jolanda
    [J]. ARTIFICIAL ORGANS, 2023, 47 (12) : 1809 - 1817
  • [49] Anatomic Fitting of Total Artificial Hearts for In Vivo Evaluation
    Gregory, Shaun D.
    Loechel, Nicole
    Pearcy, Mark J.
    Fraser, John
    Parnis, Steven
    Cohn, William E.
    Timms, Daniel
    [J]. ARTIFICIAL ORGANS, 2013, 37 (08) : 735 - 741
  • [50] Are we there yet? cellular therapies for cutaneous T cell lymphoma
    Atilla, Pinar Ataca
    Atilla, Erden
    [J]. CURRENT RESEARCH IN TRANSLATIONAL MEDICINE, 2023, 71 (02)
12345