In Search of the Holy Grail of Artificial Hearts: Are We There Yet?

被引：0

作者：

Volod, Oksana ^{[1
,4
]}

Colon, Modesto J. ^{[2
]}

Arabia, Francisco A. ^{[3
]}

机构：

[1] Cedars Sinai Med Ctr, Dept Pathol, Los Angeles, CA USA

[2] Univ Arizona, Coll Med, Dept Surg, Phoenix, AZ USA

[3] Univ Arizona, Coll Med, Dept Surg & Med, Adv Heart Program,Banner Hlth, Phoenix, AZ USA

[4] Cedars Sinai, Dept Pathol & Lab Med, 8700 Beverly Blvd,Room 4711, Los Angeles, CA 90048 USA

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2024年 / 50卷 / 01期

关键词：

total artificial heart; history; anticoagulation; TRANSPLANTATION; BRIDGE; EXPERIENCE; ANTICOAGULATION; GIBBON; JOHN; H; FAILURE; END;

D O I：

10.1055/s-0043-1772456

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The total artificial heart (TAH) has a long and rich history, being the product of decades of innovation, hard work, and dedication. This review examines the history of the TAH, a device that has revolutionized the treatment of end-stage biventricular heart failure. It reviews the development of the device from early concepts to the current state-of-the-art device, the SynCardia TAH, which has been implanted in over 2,000 patients worldwide. The article also discusses the challenges and successes experienced by researchers, clinicians, and patients throughout the development of TAH devices. Our focus will also be on discussing the hemostatic alterations in patients implanted with TAH and anticoagulation strategies to decrease associated thromboembolic risks. The article concludes with a look at other novel TAH devices and the future of TAH as an increasingly viable treatment for end-stage heart failure.

引用

页码：104 / 114

页数：11

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