Synthesis of Dibenzo[b,e]azepin-6(11H)-ones via a Sequential Ugi-4CR and Surfur Ylide-Mediated Rearrangement Reaction

被引：5

作者：

Kong, Han-Han ^{[1
,2
]}

Zhao, Long ^{[1
]}

Pan, Hong-Ling ^{[1
]}

Ding, Ming-Wu ^{[1
]}

机构：

[1] Cent China Normal Univ, Hubei Int Sci & Technol, Cooperat Base Pesticide & Green Synth, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China

[2] China Three Gorges Univ, Coll Mat & Chem Engn, Key Lab Inorgan Nonmet Crystalline & Energy Conver, Yichang 443002, Hubei, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 26卷 / 13期

基金：

中国国家自然科学基金;

关键词：

cyclization; dibenzo[b; e]azepin-6(11H)-one; rearrangement reaction; sulfur ylide; ugi reaction; SULFUR YLIDES; CYCLIZATION REACTIONS; MICHAEL ADDITION; CONSTRUCTION; CASCADE; CONCISE; UGI; HETEROCYCLES; DERIVATIVES; EPOXIDATION;

D O I：

10.1002/ejoc.202300127

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new one-pot preparation of dibenzo[b,e]azepin-6(11H)-one by a sequential Ugi-4CR and surfur ylide-mediated rearrangement reaction has been developed. A series of polysubstituted dibenzo[b,e]azepin-6(11H)-ones were obtained in 69-84 % yields from readily available sulfonium salts, 2-aminophenyl ketones, aldehydes and isocyanides in the presence of DBU.

引用

页数：5

共 57 条

[1]

[Anonymous], 2011, Angew. Chem

[2]

[Anonymous], 2009, Angew. Chem

[3] Set-up of a new series of HDAC inhibitors: the 5,11-dihydrodibenzo[b,e]azepin-6-ones as privileged structures [J].