Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia

被引:6
作者
Calvello, Rosa [1 ]
Porro, Chiara [2 ]
Lofrumento, Dario Domenico [3 ]
Ruggiero, Melania [1 ]
Panaro, Maria Antonietta [1 ]
Cianciulli, Antonia [1 ]
机构
[1] Univ Bari, Dept Biosci Biotechnol & Environm, I-70125 Bari, Italy
[2] Univ Foggia, Dept Clin & Expt Med, I-71100 Foggia, Italy
[3] Univ Salento, Dept Biol & Environm Sci & Technol, Sect Human Anat, I-73100 Lecce, Italy
关键词
microglia; resveratrol; decoy receptors; lipopolysaccharide; cytokines; INTERLEUKIN-1; RECEPTORS; NEUROINFLAMMATION; QUANTITATION; INFLAMMATION; SOCS-1;
D O I
10.3390/cells12050681
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Resveratrol is a polyphenol that acts as antioxidants do, protecting the body against diseases, such as diabetes, cancer, heart disease, and neurodegenerative disorders, such as Alzheimer's (AD) and Parkinson's diseases (PD). In the present study, we report that the treatment of activated microglia with resveratrol after prolonged exposure to lipopolysaccharide is not only able to modulate pro-inflammatory responses, but it also up-regulates the expression of decoy receptors, IL-1R2 and ACKR2 (atypical chemokine receptors), also known as negative regulatory receptors, which are able to reduce the functional responses promoting the resolution of inflammation. This result might constitute a hitherto unknown anti-inflammatory mechanism exerted by resveratrol on activated microglia.
引用
收藏
页数:14
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