Fluorescent proteins and genetically encoded biosensors

被引：79
作者：
Wang, Minji [1 ]
Da, Yifan [1 ]
Tian, Yang [1 ]
机构：
[1] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 3663 Zhong Shan Rd North, Shanghai 200062, Peoples R China
来源：
CHEMICAL SOCIETY REVIEWS | 2023年 / 52卷 / 04期
基金：
美国国家科学基金会;
关键词：
RESONANCE ENERGY-TRANSFER; LARGE STOKES SHIFT; AGGREGATION-INDUCED EMISSION; DISULFIDE BOND FORMATION; FRET-BASED SENSORS; IN-VIVO; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; LIVING CELLS; ENDOPLASMIC-RETICULUM;
D O I：
10.1039/d2cs00419d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The genetically encoded fluorescent sensors convert chemical and physical signals into light. They are powerful tools for the visualisation of physiological processes in living cells and freely moving animals. The fluorescent protein is the reporter module of a genetically encoded biosensor. In this study, we first review the history of the fluorescent protein in full emission spectra on a structural basis. Then, we discuss the design of the genetically encoded biosensor. Finally, we briefly review several major types of genetically encoded biosensors that are currently widely used based on their design and molecular targets, which may be useful for the future design of fluorescent biosensors.
引用
收藏
页码：1189 / 1214
页数：27
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