Lipid metabolism, amino acid metabolism, and prostate cancer: a crucial metabolic journey

被引：12

作者：

Chen, Lin ^{[1
,2
]}

Xu, Yu-Xin ^{[1
,2
]}

Wang, Yuan-Shuo ^{[3
]}

Zhou, Jian-Liang ^{[1
,2
]}

机构：

[1] Hangzhou Normal Univ, Sch Pharm, Hangzhou 311121, Peoples R China

[2] Hangzhou Normal Univ, Key Lab Elemene Class Anticanc Chinese Med Collabo, Engn Lab Dev & Applicat Tradit Chinese Med, Hangzhou 311121, Peoples R China

[3] Guangxi Med Univ, Sch Pharm, Nanning 530021, Peoples R China

来源：

ASIAN JOURNAL OF ANDROLOGY | 2024年 / 26卷 / 02期

基金：

中国国家自然科学基金;

关键词：

amino acid metabolism; lipid metabolism; metabolic pathways; prostate cancer; treatment strategies; ATP CITRATE LYASE; SYNTHASE; EXPRESSION; COENZYME; ENZYME; PROGRESSION; ACTIVATION; METHIONINE; INHIBITORS; ALBUMIN;

D O I：

10.4103/aja202363

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

Prostate cancer (PCa) is one of the most common malignancies in males worldwide, and its development and progression involve the regulation of multiple metabolic pathways. Alterations in lipid metabolism affect the proliferation and metastatic capabilities of PCa cells. Cancer cells increase lipid synthesis and regulate fatty acid oxidation to meet their growth and energy demands. Similarly, changes occur in amino acid metabolism in PCa. Cancer cells exhibit an increased demand for specific amino acids, and they regulate amino acid transport and metabolic pathways to fulfill their proliferation and survival requirements. These changes are closely associated with disease progression and treatment response in PCa cells. Therefore, a comprehensive investigation of the metabolic characteristics of PCa is expected to offer novel insights and approaches for the early diagnosis and treatment of this disease.

引用

页码：123 / 134

页数：12

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