Reprogramming Cell Identity: Past Lessons, Challenges, and Future Directions

被引：2

作者：

Silva, Jose C. R. ^{[1
,2
]}

机构：

[1] Guangzhou Int Bio Isl, Guangzhou Natl Lab, Guangzhou, Peoples R China

[2] Guangzhou Int Bio Isl, Guangzhou Natl Lab, Guangzhou 510005, Peoples R China

来源：

CELLULAR REPROGRAMMING | 2023年 / 25卷 / 05期

关键词：

reprogramming; induced pluripotency; cell transdifferentiation; induced pluripotent stem cells; embryonic stem cells; Stembryo; PLURIPOTENT STEM-CELLS; GROUND-STATE PLURIPOTENCY; TRANSCRIPTION FACTORS; HEMATOPOIETIC STEM; SOMATIC-CELLS; INDUCTION; FIBROBLASTS; CONVERSION; GENERATION; HALLMARKS;

D O I：

10.1089/cell.2023.0100

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Reprogramming is traditionally defined as the fate conversion of a cell to a stage of increased developmental potential. In its broader meaning, the reprogramming term is also applied to all forms of cell fate conversion that do not follow a developmental trajectory. Reprogramming is now a well-established field of research that gained rapid progress upon the advent of induced pluripotency. In this perspective, I reflect on the reprogramming lessons of the past, in the contributions to other fields of research and on the potential transformative future use of reprogrammed cells and of its cell derivatives.

引用

页码：183 / 186

页数：4

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