Epigenetic memory of coronavirus infection in innate immune cells and their progenitors

被引：121

作者：

Cheong, Jin-Gyu ^{[1
,2
]}

Ravishankar, Arjun ^{[1
,2
]}

Sharma, Siddhartha ^{[3
]}

Parkhurst, Christopher N. ^{[5
]}

Grassmann, Simon A. ^{[6
]}

Wingert, Claire K. ^{[6
]}

Laurent, Paoline ^{[7
]}

Ma, Sai ^{[8
,9
]}

Paddock, Lucinda ^{[1
]}

Miranda, Isabella C. ^{[5
]}

Karakaslar, Emin Onur ^{[3
,21
]}

Nehar-Belaid, Djamel ^{[3
]}

Thibodeau, Asa ^{[3
]}

Bale, Michael J. ^{[1
,2
]}

Kartha, Vinay K. ^{[8
,9
]}

Yee, Jim K. ^{[1
]}

Mays, Minh Y. ^{[1
]}

Jiang, Chenyang ^{[1
]}

Daman, Andrew W. ^{[1
,2
]}

de Paz, Alexia Martinez ^{[1
]}

Ahimovic, Dughan ^{[1
,2
]}

Ramos, Victor ^{[10
]}

Lercher, Alexander ^{[10
]}

Nielsen, Erik ^{[1
,5
]}

Alvarez-Mulett, Sergio ^{[5
]}

Zheng, Ling ^{[1
]}

Earl, Andrew ^{[8
,9
]}

Yallowitz, Alisha ^{[1
]}

Robbins, Lexi ^{[1
]}

Lafond, Elyse ^{[11
]}

Weidman, Karissa L. ^{[5
]}

Racine-Brzostek, Sabrina ^{[1
]}

Yang, He S. ^{[1
]}

Price, David R.

Leyre, Louise ^{[1
,2
]}

Rendeiro, Andre F. ^{[12
,13
,14
]}

Ravichandran, Hiranmayi ^{[13
,15
]}

Kim, Junbum ^{[12
]}

Borczuk, Alain C. ^{[1
,16
]}

Rice, Charles M. ^{[10
]}

Jones, R. Brad ^{[17
,18
]}

Schenck, Edward J. ^{[5
]}

Kaner, Robert J. ^{[19
]}

Chadburn, Amy ^{[1
]}

Zhao, Zhen ^{[1
]}

Pascual, Virginia ^{[20
]}

Elemento, Olivier ^{[12
,13
]}

Schwartz, Robert E. ^{[5
]}

Buenrostro, Jason D. ^{[8
,9
]}

Niec, Rachel E. ^{[5
,10
]}

机构：

[1] Weill Cornell Med, Dept Pathol & Lab Med, New York, NY 10065 USA

[2] Weill Cornell Med, Immunol & Microbial Pathogenesis Program, New York, NY 10065 USA

[3] Jackson Lab Genom Med, Farmington, CT 06032 USA

[4] Univ Connecticut, Hlth Ctr, Inst Syst Genom, Farmington, CT USA

[5] Weill Cornell Med, Dept Med, New York, NY 10065 USA

[6] Mem Sloan Kettering Canc Ctr, Immunol Program, New York, NY 10065 USA

[7] Hosp Special Surg, HSS Res Inst, New York, NY 10021 USA

[8] Broad Inst MIT & Harvard, Gene Regulat Observ, Cambridge, MA 02142 USA

[9] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02142 USA

[10] Rockefeller Univ, New York, NY 10065 USA

[11] NYU Langone Hlth, New York, NY 10016 USA

[12] Weill Cornell Med, Inst Computat Biomed, New York, NY 10065 USA

[13] Weill Cornell Med, Caryl & Israel Englander Inst Precis Med, New York, NY 10065 USA

[14] Austrian Acad Sci, CeMM Res Ctr Mol Med, A-1090 Vienna, Austria

[15] Weill Cornell Med, Dept Physiol & Biophys, New York, NY 10065 USA

[16] North Shore Univ Hosp, Dept Pathol & Lab Med, Greenvale, NY 11548 USA

[17] Weill Cornell Med, Div Infect Dis, Dept Med, New York, NY 10065 USA

[18] Weill Cornell Med, Dept Microbiol & Immunol, New York, NY 10065 USA

[19] Weill Cornell Med, Dept Genet Med, New York, NY 10065 USA

[20] Weill Cornell Med, Gale & Ira Drukier Inst Childrens Hlth, Dept Pediat, New York, NY 10065 USA

[21] Leiden Univ, Med Ctr LUMC, Leiden, Netherlands

来源：

CELL | 2023年 / 186卷 / 18期

关键词：

INDUCED TRAINED IMMUNITY; NONSPECIFIC PROTECTION; STEM-CELLS; PACKAGE; HEALTH; IL-6; MYELOPOIESIS; REINFECTION; MACROPHAGE; CHROMATIN;

D O I：

10.1016/j.cell.2023.07.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammation can trigger lasting phenotypes in immune and non-immune cells. Whether and how human infections and associated inflammation can form innate immune memory in hematopoietic stem and progenitor cells (HSPC) has remained unclear. We found that circulating HSPC, enriched from peripheral blood, captured the diversity of bone marrow HSPC, enabling investigation of their epigenomic reprogramming following coronavirus disease 2019 (COVID-19). Alterations in innate immune phenotypes and epigenetic programs of HSPC persisted for months to 1 year following severe COVID-19 and were associated with distinct transcription factor (TF) activities, altered regulation of inflammatory programs, and durable increases in myelopoiesis. HSPC epigenomic alterations were conveyed, through differentiation, to progeny innate immune cells. Early activity of IL-6 contributed to these persistent phenotypes in human COVID-19 and a mouse coronavirus infection model. Epigenetic reprogramming of HSPC may underlie altered immune function following infection and be broadly relevant, especially for millions of COVID-19 survivors.

引用

页码：3882 / +

页数：46

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