Profile of Lasmiditan in the Acute Treatment of Migraine in Adults: Design, Development, and Place in Therapy

被引:1
作者
Anderson, Christopher C. [1 ]
VanderPluym, Juliana H. [1 ]
机构
[1] Mayo Clin, Dept Neurol, 13400 E Shea Blvd, Scottsdale, AZ 85259 USA
来源
DRUG DESIGN DEVELOPMENT AND THERAPY | 2023年 / 17卷
基金
美国医疗保健研究与质量局;
关键词
lasmiditan; ditan; 5-HT1F agonist; migraine; rescue therapy; acute treatment; 5-HT1F RECEPTOR; HUMAN BRAIN; EFFICACY; ARTERIES; ATTACKS; SAFETY;
D O I
10.2147/DDDT.S380440
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Migraine is a common neurological disorder that is present in a large proportion of the global population. It is estimated to occur in around 20.7% of women and 10.7% of men in the United States. The pathophysiology of migraine is a major focus of research, and medications have been developed to interrupt the processes that generate headache and other bothersome symptoms of migraine attacks. The triptan class of medications acts as a direct agonist at the 5-HT1B/D receptor but its use is limited by contraindications for those with coronary or cerebrovascular disease. Lasmiditan is a first-in-class agonist at the 5-HT1F serotonin receptor that does not appear to generate vasoconstriction. This article reviews the design, development, and place in therapy for lasmiditan. A narrative review of the literature using the Ovid MEDLINE database was performed. The rationale behind the development of lasmiditan and pre-clinical, proof-of-concept, Phase II, pivotal, Phase III trials and post-hoc data is covered. Additionally, the efficacy and safety of lasmiditan when compared to other acute treatments in migraine is described, including lasmiditan's side effect profile and status as a Schedule V substance. Further, head-to-head studies of lasmiditan compared with other acute treatments are required.
引用
收藏
页码:1979 / 1993
页数:15
相关论文
共 55 条
[1]   CLONING OF ANOTHER HUMAN SEROTONIN RECEPTOR (5-HT1F) - A 5TH 5-HT1 RECEPTOR SUBTYPE COUPLED TO THE INHIBITION OF ADENYLATE-CYCLASE [J].
ADHAM, N ;
KAO, HT ;
SCHECHTER, LE ;
BARD, J ;
OLSEN, M ;
URQUHART, D ;
DURKIN, M ;
HARTIG, PR ;
WEINSHANK, RL ;
BRANCHEK, TA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (02) :408-412
[2]   Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study [J].
Amin, Faisal Mohammad ;
Asghar, Mohammad Sohail ;
Hougaard, Anders ;
Hansen, Adam Espe ;
Larsen, Vibeke Andree ;
de Koning, Patrick J. H. ;
Larsson, Henrik B. W. ;
Olesen, Jes ;
Ashina, Messoud .
LANCET NEUROLOGY, 2013, 12 (05) :454-461
[3]   Randomized, controlled trial of lasmiditan over four migraine attacks: Findings from the CENTURION study [J].
Ashina, Messoud ;
Reuter, Uwe ;
Smith, Timothy ;
Krikke-Workel, Judith ;
Klise, Suzanne R. ;
Bragg, Sonja ;
Doty, Erin G. ;
Dowsett, Sherie A. ;
Lin, Qun ;
Krege, John H. .
CEPHALALGIA, 2021, 41 (03) :294-304
[4]   Onset of Efficacy Following Oral Treatment With Lasmiditan for the Acute Treatment of Migraine: Integrated Results From 2 Randomized Double-Blind Placebo-Controlled Phase 3 Clinical Studies [J].
Ashina, Messoud ;
Vasudeva, Raghavendra ;
Jin, Leah ;
Lombard, Louise ;
Gray, Elizabeth ;
Doty, Erin G. ;
Yunes-Medina, Laura ;
Kinchen, Kraig S. ;
Tassorelli, Cristina .
HEADACHE, 2019, 59 (10) :1788-1801
[5]   Understanding Migraine through the Lens of Maladaptive Stress Responses: A Model Disease of Allostatic Load [J].
Borsook, David ;
Maleki, Nasim ;
Becerra, Lino ;
McEwen, Bruce .
NEURON, 2012, 73 (02) :219-234
[6]  
Bouchelet I, 1996, MOL PHARMACOL, V50, P219
[7]   No contractile effect for 5-HT1D and 5-HT1F receptor agonists in human and bovine cerebral arteries:: similarity with human coronary artery [J].
Bouchelet, I ;
Case, B ;
Olivier, A ;
Hamel, E .
BRITISH JOURNAL OF PHARMACOLOGY, 2000, 129 (03) :501-508
[8]   Interim results of a prospective, randomized, open-label, Phase 3 study of the long-term safety and efficacy of lasmiditan for acute treatment of migraine (the GLADIATOR study) [J].
Brandes, Jan Lewis ;
Klise, Suzanne ;
Krege, John H. ;
Case, Michael ;
Khanna, Rashna ;
Vasudeva, Raghavendra ;
Raskin, Joel ;
Pearlman, Eric M. ;
Kudrow, David .
CEPHALALGIA, 2019, 39 (11) :1343-1357
[9]  
Brandes JL., 2020, Cephalalgia Rep, V3, p2515816320958176, DOI [10.1177/2515816320958176, DOI 10.1177/2515816320958176]
[10]   The prevalence and impact of migraine and severe headache in the United States: Updated age, sex, and socioeconomic-specific estimates from government health surveys [J].
Burch, Rebecca ;
Rizzoli, Paul ;
Loder, Elizabeth .
HEADACHE, 2021, 61 (01) :60-68