An evaluation of the AggreGuide A-100 ADP Assay for measuring the effect of antiplatelet agents targeting the P2Y12 receptor

被引：0

作者：

Tantry, Udaya S. ^{[1
]}

Ramotowski, Bogumil ^{[2
]}

Kundan, Parshotam ^{[1
]}

Gurbel, Paul A. ^{[1
]}

机构：

[1] Sinai Hosp Baltimore, Sinai Ctr Thrombosis Res, Baltimore, MD 21215 USA

[2] Ctr Postgrad Med Educ, Dept Cardiol, Warsaw, Poland

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2023年 / 23卷 / 07期

关键词：

platelet aggregation; Platelet function assay; AggreGuide A-100 ADP assay; clopidogrel; prasugrel; ticagrelor; ADENOSINE-DIPHOSPHATE; PLATELETS;

D O I：

10.1080/14737159.2023.2224166

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

IntroductionCurrently available platelet function assays largely ignore the important characteristics of in vivo thrombus generation, such as flow conditions and shear. The AggreGuide A-100 ADP Assay detects platelet aggregation in whole blood using light scattering under flow conditions.Areas coveredIn this review article, we discuss the limitations of currently available platelet function assays and the technology underlying the AggreGuide A-100 ADP assay. We also discuss the results of the validation assay study.Expert OpinionBy incorporating arterial flow conditions and shear, the AggreGuide assay may be more indicative of in vivo thrombus generation as compared to currently available platelet function assays. As per the United States, Food and Drug administration, the AggreGuide A-100 ADP test has been cleared to assess antiplatelet effects of prasugrel and ticagrelor. The assay results are comparable to widely used VerifyNow PRU assay. The utility of AggreGuide A100-ADP Assay in guiding P2Y12 receptor inhibitor therapy in patients with cardiovascular disease needs to be explored in clinical studies.

引用

页码：555 / 560

页数：6

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