Emergence of NDM-1-producing Pseudomonas aeruginosa Sequence Type 773 Clone: Shift of Carbapenemase Molecular Epidemiology and Spread of 16S rRNA Methylase Genes in Korea

被引：16

作者：

Choi, Yu Jeong ^{[1
]}

Kim, Young Ah ^{[2
]}

Junglim, Kim ^{[3
]}

Jeong, Seok Hoon ^{[1
,3
]}

Shin, Jong Hee ^{[4
]}

Shin, Kyeong Seob ^{[5
]}

Shin, Jeong Hwan ^{[6
,7
]}

Kim, Young Ree ^{[8
]}

Kim, Hyun Soo ^{[9
]}

Uh, Young ^{[10
]}

Ryoo, Nam Hee ^{[11
]}

机构：

[1] Yonsei Univ, Dept Lab Med, Coll Med, Seoul, South Korea

[2] Ilsan Hosp, Dept Lab Med, Natl Hlth Insurance Serv, Goyang, South Korea

[3] Res Inst Bacterial Resistance, Seoul, South Korea

[4] Chonnam Natl Univ, Med Sch, Dept Lab Med, Gwangju, South Korea

[5] Chungbuk Natl Univ, Coll Med, Dept Lab Med, Cheongju, South Korea

[6] Inje Univ, Dept Lab Med, Coll Med, Busan, South Korea

[7] Inje Univ, Paik Inst Clin Res, Coll Med, Busan, South Korea

[8] Jeju Natl Univ, Coll Med, Dept Lab Med, Jeju, South Korea

[9] Hallym Univ, Dept Lab Med, Dongtan Sacred Heart Hosp, Coll Med, Hwaseong, South Korea

[10] Yonsei Univ, Dept Lab Med, Wonju Coll Med, Wonju, South Korea

[11] Keimyung Univ, Dept Lab Med, Sch Med, Daegu, South Korea

来源：

ANNALS OF LABORATORY MEDICINE | 2023年 / 43卷 / 02期

关键词：

Key Words; Pseudomonas aeruginosa; Molecular Epidemiology; -lactamase NDM-1; Se-quence type 773; Amikacin; 16S rRNA methylase gene; PSEUDOMONAS-AERUGINOSA ST235; DISSEMINATION;

D O I：

10.3343/alm.2023.43.2.196

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Imipenemase (IMP)-6-producing Pseudomonas aeruginosa sequence type (ST) 235 is a dominant clone of carbapenemase-producing P. aeruginosa (CPPAE) in Korea. As part of the Antimicrobial Resistance Surveillance System in Korea, we found an increase in the carbapenem resistance rate of P. aeruginosa isolates from blood cultures and a shift in the molecular epidemiology of CPPAE. A total of 212 non-duplicated P. aeruginosa blood iso-lates were obtained from nine general hospitals and two nursing homes. Twenty-four iso-lates were identified as CPPAE. We observed the emergence of the NDM-1 P. aeruginosa ST 773 clone (N= 10), mostly from Gyeongsang Province. The IMP-6 ST 235 clone (N= 11) was detected in all provinces. CPPAE isolates showed very high resistance rates to amika-cin, and all NDM-1 P. aeruginosa strains carried rmtB. This is the first nationwide surveil-lance of the recently emerged NDM-1-producing P. aeruginosa ST773 clone in Korea. Continuous surveillance is necessary to prevent the infection and transmission of carbape- nem-and amikacin-resistant P. aeruginosa in Korea.

引用

页码：196 / 199

页数：4

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