Eosinophilic Fasciitis: Current and Remaining Challenges

被引:23
作者
Mazilu, Diana [1 ,2 ]
Boltasiu , Laura Alina [1 ]
Mardale, Denise-Ani [1 ,2 ]
Bija, Maria Silviana [1 ]
Ismail, Sermina [1 ]
Zanfir, Violeta [1 ]
Negoi, Florentina [1 ]
Balanescu, Andra Rodica [1 ,2 ]
机构
[1] Sfanta Maria Clin Hosp, Ion Mihalache blvd, 37-39, Bucharest 011172, Romania
[2] Carol Davila Univ Med, Dionisie Lupu St 37, Bucharest 020021, Romania
关键词
eosinophilic fasciitis; Shulman; systemic sclerosis; NIVOLUMAB; PATIENT;
D O I
10.3390/ijms24031982
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Eosinophilic fasciitis (EF), defined as diffuse fasciitis with eosinophilia by Shulman in 1974, is a disease with unknown etiology and whose pathogenesis is still being researched. The diagnosis is based on the clinical aspects (skin induration with an "orange peel" appearance), the lab results (eosinophilia, increased inflammatory markers), the skin biopsy with the pathognomonic histopathological result, as well as the typical MRI changes. The treatment includes glucocorticoids and immunosuppressive drugs. Due to severe refractory cases, the treatment remains a challenge. EF is still a disease with potential for further research.
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页数:9
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