Exploring multi-omics strategies for herbal treatment of drug-resistant epilepsy: a comprehensive review

被引:2
作者
Wasim, Muhammad [1 ,2 ,3 ]
Siddiqi, Hasan Salman [1 ]
Ahmad, Saara [1 ]
Arain, Fazal Manzoor [1 ,3 ]
机构
[1] Aga Khan Univ, Dept Biol & Biomed Sci, Karachi 74800, Pakistan
[2] Univ Lahore, Sch Pain & Regenerat Med, Punjab 54000, Pakistan
[3] Aga Khan Univ, Dept Biol & Biomed Sci, Stadium Rd, Karachi 74800, Pakistan
关键词
traditional medicine; GABA receptors; glutamate receptors; multi-omics; temporal lobe epilepsy; TEMPORAL-LOBE EPILEPSY; TRADITIONAL CHINESE MEDICINE; SEMIALDEHYDE DEHYDROGENASE; ANTIEPILEPTIC DRUGS; MYOCLONIC EPILEPSY; STATUS-EPILEPTICUS; MECHANISMS; SEIZURES; GENE; MUTATION;
D O I
10.53388/TMR20231117001
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Epilepsy affects approximately 70 million people worldwide. Yet scientists have a partial understanding of the disease pathophysiology due to its heterogenic nature. About 70% of cases of epilepsy are treatable with FDA -approved anti -epileptic drugs while temporal lobe epilepsy with hippocampus sclerosis (TLE-HS) is drug resistant. Numerous herbs have been noted for their potential anti-convulsant properties. Yet, due to the scarcity of experimental data, there is an urgent need to conduct thorough investigations into these herbs for their practical use in treating TLE-HS. In-depth multi-omics research is needed for targeted TLE-HS therapy, focusing on cornu ammonis subregions, dentate gyrus, and also genetically glutamate, and gamma-aminobutyric acid receptors. Animal models, due to the lack of human brain tissue, enable homogeneous sample selection, comparable groups, and ample tissue for in -vitro and ex -vivo studies. Consequently, it becomes feasible to examine the effectiveness of herbs on individual brain regions at the molecular level, paving the way for the potential development of drug interventions to treat TLE-HS.
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页数:12
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