Clinical trial implementation: a primer for neurosurgeons

被引：1
作者：
Jimenez, Adrian E. [1 ]
Kotecha, Rupesh [2 ]
Mukherjee, Debraj [1 ,3 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD USA
[2] Miami Canc Inst, Dept Radiat Oncol, Baptist Hlth South Florida, Miami, FL USA
[3] Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA
来源：
JOURNAL OF NEUROSURGERY | 2023年 / 139卷 / 05期
关键词：
clinical trials; neurosurgery; RCT; randomized controlled trial; DECOMPRESSIVE CRANIECTOMY; END-POINTS; DESIGN; SURVIVAL; QUALITY; CARE;
D O I：
10.3171/2023.2.JNS221937
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In the current landscape of evidence-based medicine, prospective clinical trials are an important avenue through which to establish the efficacy and safety of biomedical treatments compared with standard-of-care interventions. Depending on their scope and aims, clinical trials can be extremely costly and time intensive, and significant coordination is needed to ensure optimal utilization of healthcare resources, adherence to the principles of biomedical ethics, and appropriate interpretation of study results. This review highlights the core principles for designing and implementing clinical trials within neurosurgery, with the aim to provide clinicians with a framework for implementing both investigator-initiated and industry-sponsored trials.
引用
收藏
页码：1439 / 1445
页数：7
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