The Evolution of Tumor Microenvironment in Gliomas and Its Implication for Target Therapy

被引：16

作者：

Hu, Yang ^{[1
,2
]}

Li, Zhixing ^{[1
,2
]}

Zhang, Yichi ^{[1
,2
]}

Wu, Yuzheng ^{[1
,2
]}

Liu, Zihao ^{[1
,2
]}

Zeng, Jianhao ^{[4
]}

Hao, Zhexue ^{[1
,2
]}

Li, Jin ^{[1
,2
]}

Ren, Jiaoyan ^{[3
]}

Yao, Maojin ^{[1
,2
]}

机构：

[1] Guangzhou Med Univ, Guangzhou Inst Resp Dis, Affiliated Hosp 1, Guangzhou 510182, Peoples R China

[2] China State Key Lab Resp Dis, Guangzhou 510182, Peoples R China

[3] South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510641, Peoples R China

[4] Univ Virginia Hlth Syst, Dept Microbiol Immunol & Canc Biol, Charlottesville, VA 22908 USA

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2023年 / 19卷 / 13期

基金：

中国国家自然科学基金;

关键词：

Glioma; Tumor microenvironment; Tumor evolution; Targeted therapy; Mouse model; OLIGODENDROCYTE PRECURSOR CELLS; REGULATORY T-CELLS; CENTRAL-NERVOUS-SYSTEM; BLOOD-BRAIN-BARRIER; NEURONAL-ACTIVITY; PERIPHERAL MACROPHAGES; RESIDENT MICROGLIA; HUMAN GLIOBLASTOMA; PROGNOSTIC IMPACT; CLINICAL-TRIAL;

D O I：

10.7150/ijbs.83531

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gliomas develop in unique and complicated environments that nourish tumor cells. The tumor microenvironment (TME) of gliomas comprises heterogeneous cells, including brain-resident cells, immune cells, and vascular cells. Reciprocal interactions among these cells are involved in the evolution of the TME. Moreover, the study of attractive therapeutic strategies that target the TME is transitioning from basic research to the clinic. Mouse models are indispensable tools for dissecting the processes and mechanisms leading to TME evolution. In this review, we overview the paradoxical roles of the TME, as well as the recent progress of mouse models in TME research. Finally, we summarize recent advances in TME-targeting therapeutic strategies.

引用

页码：4311 / 4326

页数：16

共 127 条

[1] A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules [J].

Aspelund, Aleksanteri ;

Antila, Salli ;

Proulx, Steven T. ;

Karlsen, Tine Veronica ;

Karaman, Sinem ;

Detmar, Michael ;

Wiig, Helge ;

Alitalo, Kari .

JOURNAL OF EXPERIMENTAL MEDICINE, 2015, 212 (07) :991-999

[2] Human Glioblastoma Stem-Like Cells are More Sensitive to Allogeneic NK and T Cell-Mediated Killing Compared with Serum-Cultured Glioblastoma Cells [J].

Avril, Tony ;

Vauleon, Elodie ;

Hamlat, Abderrahmane ;

Saikali, Stephan ;

Etcheverry, Amandine ;

Delmas, Caroline ;

Diabira, Sylma ;

Mosser, Jean ;

Quillien, Veronique .

BRAIN PATHOLOGY, 2012, 22 (02) :159-174

[3] Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor [J].

Bao, Shideng ;

Wu, Qiulian ;

Sathornsumetee, Sith ;

Hao, Yueling ;

Li, Zhizhong ;

Hjelmeland, Anita B. ;

Shi, Oing ;

McLendon, Roger E. ;

Bigner, Darell D. ;

Rich, Jeremy N. .

CANCER RESEARCH, 2006, 66 (16) :7843-7848

[4] PROLIFERATION OF OLIGODENDROCYTE PRECURSOR CELLS DEPENDS ON ELECTRICAL-ACTIVITY IN AXONS [J].

BARRES, BA ;

RAFF, MC .

NATURE, 1993, 361 (6409) :258-260

[5] AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients [J].

Batchelor, Tracy T. ;

Sorensen, A. Gregory ;

di Tomaso, Emmanuelle ;

Zhang, Wei-Ting ;

Duda, Dan G. ;

Cohen, Kenneth S. ;

Kozak, Kevin R. ;

Cahill, Daniel P. ;

Chen, Poe-Jou ;

Zhu, Mingwang ;

Ancukiewicz, Marek ;

Mrugala, Maciej M. ;

Plotkin, Scott ;

Drappatz, Jan ;

Louis, David N. ;

Ivy, Percy ;

Scadden, David T. ;

Benner, Thomas ;

Loeffler, Jay S. ;

Wen, Patrick Y. ;

Jain, Rakesh K. .

CANCER CELL, 2007, 11 (01) :83-95

[6] Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus [J].

Bergles, DE ;

Roberts, JDB ;

Somogyi, P ;

Jahr, CE .

NATURE, 2000, 405 (6783) :187-191

[7] Microglia promote glioma migration [J].

Bettinger, I ;

Thanos, S ;

Paulus, W .

ACTA NEUROPATHOLOGICA, 2002, 103 (04) :351-355

[8] Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages [J].

Bloch, Orin ;

Crane, Courtney A. ;

Kaur, Rajwant ;

Safaee, Michael ;

Rutkowski, Martin J. ;

Parsa, Andrew T. .

CLINICAL CANCER RESEARCH, 2013, 19 (12) :3165-3175

[9] Astrocytes, the rising stars of the glioblastoma microenvironment [J].

Brandao, Mayra ;

Simon, Thomas ;

Critchley, Giles ;

Giamas, Georgios .

GLIA, 2019, 67 (05) :779-790

[10] Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors [J].

Brandenburg, Susan ;

Mueller, Annett ;

Turkowski, Kati ;

Radev, Yordan T. ;

Rot, Sergej ;

Schmidt, Christin ;

Bungert, Alexander D. ;

Acker, Gueliz ;

Schorr, Anne ;

Hippe, Andreas ;

Miller, Kelly ;

Heppner, Frank L. ;

Homey, Bernhard ;

Vajkoczy, Peter .

ACTA NEUROPATHOLOGICA, 2016, 131 (03) :365-378

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