Severe anemia is associated with increased short-term and long-term mortality in patients hospitalized with cirrhosis

被引：4

作者：

Ren, Haotang ^{[1
]}

Li, Hai ^{[2
,3
]}

Deng, Guohong ^{[4
]}

Wang, Xianbo ^{[5
]}

Zheng, Xin ^{[6
]}

Huang, Yan ^{[7
]}

Chen, Jinjun ^{[8
]}

Meng, Zhongji ^{[9
]}

Gao, Yanhang ^{[10
]}

Qian, Zhiping ^{[11
]}

Liu, Feng ^{[12
]}

Lu, Xiaobo ^{[13
]}

Shang, Jia ^{[14
]}

Wang, Shaoyang ^{[15
]}

Yin, Shan ^{[2
,3
]}

Tan, Wenting ^{[4
]}

Hou, Yixin ^{[5
]}

Xiong, Shue ^{[6
]}

Long, Liyuan ^{[7
]}

Li, Beiling ^{[8
]}

Luo, Sen ^{[9
]}

Zhang, Weituo ^{[16
]}

Shi, Yu ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Sch Med,Collaborat Innovat Ctr Diag & Treatment I, Hangzhou, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Dept Gastroenterol, Ren Ji Hosp, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Key Lab Gastroenterol & Hepatol, Shanghai Inst Digest Dis, Chinese Minist Hlth, Shanghai, Peoples R China

[4] Third Mil Med Univ, Army Med Univ, Southwest Hosp, Dept Infect Dis, Chongqing, Peoples R China

[5] Capital Med Univ, Beijing Ditan Hosp, Ctr Integrat Med, Beijing, Peoples R China

[6] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Infect Dis,Inst Infect & Immunol, Wuhan, Hubei, Peoples R China

[7] Cent South Univ, Xiangya Hosp, Dept Infect Dis, Hunan Key Lab Viral Hepatitis, Changsha, Hunan, Peoples R China

[8] Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Hepatol Unit, Guangzhou, Peoples R China

[9] Hubei Univ Med, Taihe Hosp, Dept Infect Dis, Shiyan, Hubei, Peoples R China

[10] First Hosp Jilin Univ, Dept Hepatol, Changchun, Peoples R China

[11] Fudan Univ, Shanghai Publ Hlth Clin Ctr, Dept Liver Intens Care Unit, Shanghai, Peoples R China

[12] Shandong Univ, Dept Infect Dis & Hepatol, Hosp 2, Jinan, Peoples R China

[13] Xinjiang Med Univ, Infect Dis Ctr, Affiliated Hosp 1, Urumqi, Xinjiang, Peoples R China

[14] Henan Prov Peoples Hosp, Dept Infect Dis, Zhengzhou, Henan, Peoples R China

[15] Fuzhou Gen Hosp, Dept Infect Dis, Nanjing Mil Command, Fuzhou, Fujian, Peoples R China

[16] Shanghai Jiao Tong Univ, Clin Res Ctr, Sch Med, Shanghai, Peoples R China

来源：

ANNALS OF HEPATOLOGY | 2023年 / 28卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Cirrhosis; Acute decompensation; Liver injury; Anemia; Mortality;

D O I：

10.1016/j.aohep.2023.101147

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Introduction and Objectives: The relationship between anemia and the outcome of patients with cirrhosis is not completely clear. Therefore, we performed this large-scale epidemiological study to investigate the prevalence and severity of anemia in patients with cirrhosis and acute decompensation or liver injury and how anemia impacts short-term and long-term outcomes. Patients and Methods: Patients with cirrhosis and acute decompensation (AD) or acute liver injury (ALI) were enrolled in the Chinese AcuTe on CHronic LIver FailurE (CATCH-LIFE) studies, which consisted of two large, multicenter, prospective, observational cohorts between January 2015 and December 2016 and July 2018 and January 2019. We conducted data analysis on the prevalence of anemia and determined the relationship between anemia and prognosis. Results: Among 1979 patients, 1389 (70.2%) had anemia, among whom 599 (41.3%) had mild anemia, 595 (15.8%) had moderate anemia and 195 (2.4%) had severe anemia. A linear association between hemoglobin level and 90-day or 1-year LT-free mortality was shown, and a 10 g/L decrease in hemoglobin level was asso-ciated with a 6.8% extra risk of 90-day death and a 5.7% extra risk of 1-year death. Severe anemia was an independent risk factor for 90-day [HR=1.649 (1.100, 2.473), p=0.016] and 1-year LT-free mortality [HR=1.610 (1.159, 2.238), p=0.005]. Multinomial logistic regression analysis further identified that severe anemia was significantly associated with post-28-day mortality but not within-28-day mortality. Conclusions: Anemia is common in patients with cirrhosis admitted for acute events. Severe anemia was associated with poor 90-day and 1-year prognoses in these patients. (c) 2023 Fundacion Clinica Medica Sur, A.C. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

引用

页数：11

共 25 条

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