miRNAs as potential game-changers in bone diseases: Future medicinal and clinical uses

被引：55

作者：

Doghish, Ahmed S. ^{[1
,2
]}

Elballal, Mohammed S. ^{[1
]}

Elazazy, Ola ^{[1
]}

Elesawy, Ahmed E. ^{[1
]}

Shahin, Reem K. ^{[1
]}

Midan, Heba M. ^{[1
]}

Sallam, Al-Aliaa M. ^{[1
]}

Elbadry, Abdullah M. M. ^{[1
]}

Mohamed, Aliaa K. I. ^{[1
]}

Ishak, Nardeen W. ^{[1
]}

Hassan, Kholoud Ali ^{[1
]}

Ayoub, Amira M. ^{[1
]}

Shalaby, Rana E. ^{[1
]}

Elrebehy, Mahmoud A. ^{[1
]}

机构：

[1] Badr Univ Cairo BUC, Fac Pharm, Dept Biochem, Cairo 11829, Egypt

[2] Al Azhar Univ, Fac Pharm Boys, Biochem & Mol Biol Dept, Cairo 11231, Egypt

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2023年 / 245卷

关键词：

MiRNAs; Bone diseases; Osteoporosis; Bone cancer; Treatment; -resistant; STEROID-INDUCED OSTEONECROSIS; MESENCHYMAL STEM-CELLS; MODULATES DOXORUBICIN RESISTANCE; DNA-DAMAGE RESPONSE; OSTEOSARCOMA CELLS; OSTEOBLAST DIFFERENTIATION; OXIDATIVE STRESS; DOWN-REGULATION; BREAST-CANCER; FEMORAL-HEAD;

D O I：

10.1016/j.prp.2023.154440

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

MicroRNAs (miRNAs), short, highly conserved non-coding RNA, influence gene expression by sequential mechanisms such as mRNA breakdown or translational repression. Many biological processes depend on these regulating substances, thus changes in their expression have an impact on the maintenance of cellular homeo-stasis and result in the emergence of a variety of diseases. Relevant studies have shown in recent years that miRNAs are involved in many stages of bone development and growth. Additionally, abnormal production of miRNA in bone tissues has been closely associated with the development of numerous bone disorders, such as osteonecrosis, bone cancer, and bone metastases. Many pathological processes, including bone loss, metastasis, the proliferation of osteosarcoma cells, and differentiation of osteoblasts and osteoclasts, are under the control of miRNAs. By bringing together the most up-to-date information on the clinical relevance of miRNAs in such diseases, this study hopes to further the study of the biological features of miRNAs in bone disorders and explore their potential as a therapeutic target.

引用

页数：21

共 333 条

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