UNDIFFERENTIATED PLEOMORPHIC SARCOMA : PROGNOSTIC FACTORS IN 42 EXTREMITY CASES

被引:0
作者
Macaneiro Jr, Carlos Henrique [1 ,2 ]
Baptista, Andre Mathias [1 ]
de Camargo, Olavo Pires [1 ]
Filippi, Renee Zon [1 ]
Oliveira, Evandro Tito [1 ]
机构
[1] Univ Sao Paulo, Hosp Clin, Fac Med, Inst Ortopedia & Traumatol, Sao Paulo, SP, Brazil
[2] Rua Blumenau 1316, BR-89204251 Joinville, SC, Brazil
来源
ACTA ORTOPEDICA BRASILEIRA | 2023年 / 31卷 / 02期
关键词
Histiocytoma; Malignant Fibrous; Sarcoma; Prognosis; Recurrence; Death; Survival; MALIGNANT FIBROUS HISTIOCYTOMA; SOFT-TISSUE SARCOMAS;
D O I
10.1590/1413-785220233102e265942
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Introduction: Soft tissue undifferentiated pleomorphic sarcoma (UPS) in extremities is considered a rare neoplasm, corresponding to 5% of soft tissue sarcomas (STS) today. The objective was to evaluate prognostic factors related to death, local recurrence (LR), and impact on survival rates. Methods: A retrospective study including 42 patients with UPS in extremities treated surgically in a single center. Comparisons were made between demographic data, characteristics of the neoplasia, and treatment. Between the variables with statistical significance, logistic regression analysis was used. Survival rates were evaluated using Kaplan-Meier plots. To compare the effect of variables on survival rates, the Log-Rank test was used. Results: Age group of patients was from 25 to 85 years (mean 58 years), with a mean follow-up of 29.6 months. The variables with the highest effect on survival rates were sizes larger than 15 cm (T4) with p = 0.01, presence of metastatic lesions, and prognostic stage IV according to the American Joint Committee of Cancer (AJCC) with p < 0.001. The mean survival was 25.9 months. Metastasis and stage IV of AJCC were associated with a reduction in patient survival (17.8 months) with Log-Rank test p < 0.001. Conclusion: The main factors of poor prognosis related to mortality and reduction of survival of UPS in extremities were metastatic lesions and stage IV of AJCC. Level of Evidence III, Retrospective Study.
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页数:5
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