Clinical heterogeneity of neuro-inflammatory PET profiles in early Alzheimer's disease

被引：2

作者：

Gouilly, Dominique ^{[1
]}

Salabert, Anne-Sophie ^{[1
,2
]}

Bertrand, Elsa ^{[3
]}

Goubeaud, Marie ^{[3
]}

Catala, Helene ^{[3
]}

Germain, Johanne ^{[3
]}

Ainaoui, Nadera ^{[3
]}

Rafiq, Marie ^{[1
,4
]}

Benaiteau, Marie ^{[4
]}

Carlier, Jasmine ^{[4
]}

Nogueira, Leonor ^{[5
]}

Planton, Melanie ^{[1
,4
]}

Hitzel, Anne ^{[2
]}

Meligne, Deborah ^{[1
]}

Sarton, Benjamine ^{[1
,6
]}

Silva, Stein ^{[1
,6
]}

Lemesle, Beatrice ^{[4
]}

Payoux, Pierre ^{[1
,2
]}

Thalamas, Claire ^{[3
]}

Peran, Patrice ^{[1
]}

Pariente, Jeremie ^{[1
,3
,4
]}

机构：

[1] UPS, Toulouse Neuroimaging Ctr, UMR 1214, Inserm, Toulouse, France

[2] Toulouse Purpan Univ Hosp Ctr, Dept Nucl Med, Toulouse, France

[3] Toulouse Purpan Univ Hosp Ctr, Ctr Clin Invest CIC 1436, Toulouse, France

[4] Toulouse Purpan Univ Hosp Ctr, Dept Cognit Neurol Epilepsy & Movement Disorders, Toulouse, France

[5] Toulouse Purpan Univ Hosp Ctr, Lab Cell Biol & Cytol, Toulouse, France

[6] Toulouse Purpan Univ Hosp Ctr, Crit Care Unit, Toulouse, France

来源：

FRONTIERS IN NEUROLOGY | 2023年 / 14卷

关键词：

Alzheimer; TSPO; neuroinflammation; neuropsychology; PET scan; MICROGLIAL ACTIVATION; TRANSLOCATOR PROTEIN; NEUROINFLAMMATION; BIOMARKERS; PLAQUES; BINDING; BRAIN; TAU;

D O I：

10.3389/fneur.2023.1189278

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The relationship between neuroinflammation and cognition remains uncertain in early Alzheimer's disease (AD). We performed a cross-sectional study to assess how neuroinflammation is related to cognition using TSPO PET imaging and a multi-domain neuropsychological assessment. A standard uptake value ratio (SUVR) analysis was performed to measure [F-18]-DPA-714 binding using the cerebellar cortex or the whole brain as a (pseudo)reference region. Among 29 patients with early AD, the pattern of neuroinflammation was heterogeneous and exhibited no correlation with cognition at voxel-wise, regional or whole-brain level. The distribution of the SUVR values was independent of sex, APOE phenotype, early and late onset of symptoms and the presence of cerebral amyloid angiopathy. However, we were able to demonstrate a complex dissociation as some patients with similar PET pattern had opposed neuropsychological profiles while other patients with opposite PET profiles had similar neuropsychological presentation. Further studies are needed to explore how this heterogeneity impacts disease progression.

引用

页数：8

共 32 条

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