Role of long non-coding RNAs in pancreatic cancer pathogenesis and treatment resistance- A review

被引：48

作者：

Al-Noshokaty, Tohada M. ^{[1
]}

Mansour, Abdallah ^{[1
]}

Abdelhamid, Rehab ^{[1
]}

Abdellatif, Nourhan ^{[1
]}

Alaaeldien, Ayat ^{[1
]}

Reda, Tasnim ^{[1
]}

Abdelmaksoud, Nourhan M. ^{[1
]}

Doghish, Ahmed S. ^{[2
]}

Abulsoud, Ahmed I. ^{[1
,3
]}

Elshaer, Shereen Saeid ^{[1
,4
]}

机构：

[1] Heliopolis Univ, Fac Pharm, Dept Biochem, Cairo 11785, Egypt

[2] Badr Univ Cairo BUC, Fac Pharm, Dept Biochem, Cairo 11829, Egypt

[3] Al Azhar Univ, Fac Pharm Boys, Biochem & Mol Biol Dept, Cairo 11231, Egypt

[4] Al Azhar Univ, Fac Pharm Girls, Biochem & Mol Biol Dept, Cairo, Egypt

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2023年 / 245卷

关键词：

Pancreatic cancer; LncRNA; Pathogenesis; Treatment resistance; EPITHELIAL-MESENCHYMAL TRANSITION; PROMOTES CELL-PROLIFERATION; DUCTAL ADENOCARCINOMA; GEMCITABINE RESISTANCE; SIGNALING PATHWAY; DOWN-REGULATION; EMERGING ROLES; TUMOR-CELLS; LNCRNA; PROGRESSION;

D O I：

10.1016/j.prp.2023.154438

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Pancreatic cancer (PC) is one of the deadliest cancers associated with poor prognosis. The lack of reliable means of early cancer detection contributes to this disease's dismal prognosis. Long non-coding RNAs (LncRNAs) are protein-free RNAs produced by genome transcription; they play critical roles in gene expression regulation, epigenetic modification, cell proliferation, differentiation, and reproduction. Recent research has shown that lncRNAs play important regulatory roles in PC behaviors, in addition to their recently found functions. Several in-depth investigations have shown that lncRNAs are strongly linked to PC development and progression. Here, we discuss how lncRNAs, which are often overlooked, play many roles as regulators in the molecular mechanism underlying PC. This review also discusses the involved LncRNAs in PC pathogenesis and treatment resistance.

引用

页数：19

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