RNA Modification Related Diseases and Sensing Methods

被引：0
作者：
Ohkawa, Mayuka [1 ,2 ]
Konno, Masamitsu [1 ,3 ]
机构：
[1] Natl Inst Adv Sci & Technol AIST, Cellular & Mol Biotechnol Res Inst, Biol Data Sci Res Grp, Koto, Tokyo 1350064, Japan
[2] Tokyo Univ Sci, Res Inst Biomed Sci, Div Canc Biol, Noda, Chiba 2780022, Japan
[3] Tokyo Univ Sci, Res Inst Sci & Technol RIST, Div Med Data Sci, Noda, Chiba 2780022, Japan
来源：
APPLIED SCIENCES-BASEL | 2023年 / 13卷 / 11期
基金：
日本学术振兴会;
关键词：
epitranscriptome; RNA methylation; RNA modification sequence(s); single-molecule sensing; TRANSCRIPTOME-WIDE IDENTIFICATION; SINGLE-NUCLEOTIDE-RESOLUTION; STEM-CELL DIFFERENTIATION; MESSENGER-RNA; M(6)A METHYLTRANSFERASE; MAPPING REVEALS; GENE-EXPRESSION; METHYLATION; N-6-METHYLADENOSINE; N6-METHYLADENOSINE;
D O I：
10.3390/app13116376
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Epitranscriptomics is the study of RNA base modifications, including functionally relevant transcriptomic changes. Epitranscriptomics has been actively studied in recent years and has been reported to play important roles in development, homeostasis, the immune system, and various life phenomena such as cancer, neurological diseases, and infectious diseases. However, a major problem is the development of sequencing methods to map RNA base modifications throughout the transcriptome. In recent years, various methods for RNA base modification have been actively studied, and we are beginning to successfully measure base modifications that have been difficult to measure in previous years. In this review, we will discuss in detail the biological significance of RNA modifications and the latest techniques for detecting RNA modifications.
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页数：16
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