Incidence and Prevalence of Multisystem Inflammatory Syndrome in Children (MIS-C) in Southern Italy

被引：9

作者：

La Torre, Francesco ^{[1
]}

Elicio, Maria Pia ^{[1
]}

Monno, Viviana Anna ^{[1
]}

Chironna, Maria ^{[2
]}

Moramarco, Fulvio ^{[3
]}

Campanozzi, Angelo ^{[4
]}

Civino, Adele ^{[5
]}

Cecinati, Valerio ^{[6
]}

Vairo, Ugo ^{[7
]}

Giordano, Mario ^{[8
]}

Milella, Leonardo ^{[9
]}

Loconsole, Daniela ^{[2
]}

Cardinale, Fabio ^{[1
]}

机构：

[1] Univ Bari, Giovanni XXIII Pediat Hosp, Dept Pediat, I-70126 Bari, Italy

[2] Univ Bari, Dept Interdisciplinary Med, Hyg Sect, I-70123 Bari, Italy

[3] Antonio Perrino Hosp, Dept Pediat, I-72100 Brindisi, Italy

[4] Univ Foggia, Dept Med & Surg Sci, Pediat Sect, I-71122 Foggia, Italy

[5] Vito Fazzi Hosp, Div Pediat Rheumatol & Immunol, I-73100 Lecce, Italy

[6] SS Annunziata Hosp, Dept Pediat, I-74100 Taranto, Italy

[7] Giovanni XXIII Pediat Hosp, Div Pediat Cardiol, I-70126 Bari, Italy

[8] Giovanni XXIII Pediat Hosp, Div Pediat Nephrol & Dialysis, I-70126 Bari, Italy

[9] Giovanni XXIII Pediat Hosp, Div Intens Care, I-70126 Bari, Italy

来源：

CHILDREN-BASEL | 2023年 / 10卷 / 05期

关键词：

children; MIS-C; COVID-19; incidence; epidemiology;

D O I：

10.3390/children10050766

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Multisystem inflammatory syndrome in children (MIS-C) is a pediatric hyperinflammatory syndrome related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection whose epidemiology is not very well known at present. The objective of the study was to better understand the incidence of MIS-C in the Apulia region in southern Italy. Our primary goal was to estimate the incidence of newly identified cases of MIS-C in children aged 0-18 years, during a period of six months, encompassing the second pandemic wave. We also analyzed the characteristics of our cohort in terms of clinical features, treatment, and outcomes. The cumulative incidence of MIS-C was 3.27 per 100,000 residents between 0 and 18 years of age. In our cohort, gastrointestinal, mucocutaneous, and cardiac involvement were the most common clinical features. With our step-up approach to therapy, no patients required intensive care unit (ICU) admission and no cardiac sequelae after 6 months of onset were found in echocardiograms. Conclusion: Our epidemiological study of MIS-C in southern Italy showed unexpectedly overlapping figures with other US studies.

引用

页数：12

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