Neurobiological effects of gallic acid: current perspectives

被引：93

作者：

Bhuia, Md. Shimul ^{[1
]}

Rahaman, Md. Mizanur ^{[1
]}

Islam, Tawhida ^{[1
]}

Bappi, Mehedi Hasan ^{[1
]}

Sikder, Md. Iqbal ^{[2
]}

Hossain, Kazi Nadim ^{[1
]}

Akter, Fatama ^{[2
]}

Prottay, Abdullah Al Shamsh ^{[1
]}

Rokonuzzman, Md. ^{[1
]}

Gurer, Eda Sonmez ^{[3
]}

Calina, Daniela ^{[4
]}

Islam, Muhammad Torequl ^{[1
]}

Sharifi-Rad, Javad ^{[5
]}

机构：

[1] Bangabandhu Sheikh Mujibur Rahman Sci & Technol U, Dept Pharm, Gopalganj 8100, Bangladesh

[2] Southern Univ Bangladesh, Dept Pharm, Chattogram 4210, Bangladesh

[3] Sivas Cumhuriyet Univ, Fac Pharm, Dept Pharmacognosy, Sivas, Turkiye

[4] Univ Med & Pharm Craiova, Dept Clin Pharm, Craiova 200349, Romania

[5] Univ Azuay, Fac Med, Cuenca, Ecuador

来源：

CHINESE MEDICINE | 2023年 / 18卷 / 01期

关键词：

Gallic acid; neuroprotective activity; pharmacological effects; Molecular mechanisms; Brain health; MILD COGNITIVE IMPAIRMENT; VACUOUS CHEWING MOVEMENTS; INDUCED OXIDATIVE STRESS; PARKINSONS-DISEASE; INTRACEREBROVENTRICULAR INJECTION; ALZHEIMERS-DISEASE; REPERFUSION INJURY; PLANT POLYPHENOLS; DRUG DISCOVERY; BRAIN;

D O I：

10.1186/s13020-023-00735-7

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Gallic acid (GA) is a phenolic molecule found naturally in a wide range of fruits as well as in medicinal plants. It has many health benefits due to its antioxidant properties. This study focused on finding out the neurobiological effects and mechanisms of GA using published data from reputed databases. For this, data were collected from various sources, such as PubMed/Medline, Science Direct, Scopus, Google Scholar, SpringerLink, and Web of Science. The findings suggest that GA can be used to manage several neurological diseases and disorders, such as Alzheimer's disease, Parkinson's disease, strokes, sedation, depression, psychosis, neuropathic pain, anxiety, and memory loss, as well as neuroinflammation. According to database reports and this current literature-based study, GA may be considered one of the potential lead compounds to treat neurological diseases and disorders. More preclinical and clinical studies are required to establish GA as a neuroprotective drug.

引用

页数：19

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