Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders

被引：27

作者：

Turek, Justyna ^{[1
]}

Gasior, Lukasz ^{[1
]}

机构：

[1] Polish Acad Sci, Maj Inst Pharmacol, Dept Neurobiol, Smetna 12 St, PL-31343 Krakow, Poland

来源：

PHARMACOLOGICAL REPORTS | 2023年 / 75卷 / 01期

关键词：

Estrogen receptors; Menopause; Depression; CENTRAL-NERVOUS-SYSTEM; NEUROTROPHIC FACTOR; SEX-DIFFERENCES; RECEPTOR-BETA; POSTMENOPAUSAL WOMEN; POSSIBLE MECHANISM; SPINE DENSITY; BRAIN; FEMALE; ESTRADIOL;

D O I：

10.1007/s43440-022-00444-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Women are significantly more likely to develop depression than men. Fluctuations in the ovarian estrogen hormone levels are closely linked with women's well-being. This narrative review discusses the available knowledge on the role of estrogen in modulating brain function and the correlation between changes in estrogen levels and the development of depression. Equally discussed are the possible mechanisms underlying these effects, including the role of estrogen in modulating brain-derived neurotrophic factor activity, serotonin neurotransmission, as well as the induction of inflammatory response and changes in metabolic activity, are discussed.

引用

页码：32 / 43

页数：12

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