Synthesis and Anticancer Activity Evaluation of New Quinoline Derivatives

被引：0
|
作者：
Wang, Wenyan [1 ]
Xia, Shen [1 ]
Cheng, Zhiyun [1 ]
Jiang, Haiqing [1 ]
Zhang, Yihan [1 ]
Wan, Yichao [1 ]
机构：
[1] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Theoret Organ Chem & Funct Mol, Minist Educ, Xiangtan 411201, Peoples R China
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / SUPPL 4期
基金：
中国国家自然科学基金;
关键词：
quinoline derivatives; activity evaluation; antitumor activity; ANTITUMOR-ACTIVITY; PYRIDOXINE; HYBRIDS; ANALOGS; AGENTS;
D O I：
10.1134/S1070363223170097
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of new quinoline derivatives were designed, synthesized and evaluated for antiproliferative activity against two cancer cell lines (MCF-7 and HCCLM-3) and a human normal cell line (HEK293T cells). Among them, 3-(2,7-dimethoxyquinolin-3-yl)-1-(4-methoxyphenyl)prop-2-en-1-one displayed the most inhibitory activity against MCF-7 and HCCLM-3 cells, which were equal and better than the positive control 5-fluorouracil (82.18% vs. 83.29%, 94.79% vs. 76.98%), respectively. Additionally, it had poor inhibitory activity (48.14%) against HEK293T cells, which displayed good selectivity for cancer cells. Therefore, 3-(2,7-dimethoxyquinolin-3-yl)-1-(4-methoxyphenyl)prop-2-en-1-one could be as a lead compound to develop more potent anticancer agents.
引用
收藏
页码：S928 / S933
页数：6
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