Synthesis and Anticancer Activity Evaluation of New Quinoline Derivatives

被引：0

作者：

Wang, Wenyan ^{[1
]}

Xia, Shen ^{[1
]}

Cheng, Zhiyun ^{[1
]}

Jiang, Haiqing ^{[1
]}

Zhang, Yihan ^{[1
]}

Wan, Yichao ^{[1
]}

机构：

[1] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Theoret Organ Chem & Funct Mol, Minist Educ, Xiangtan 411201, Peoples R China

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / SUPPL 4期

基金：

中国国家自然科学基金;

关键词：

quinoline derivatives; activity evaluation; antitumor activity; ANTITUMOR-ACTIVITY; PYRIDOXINE; HYBRIDS; ANALOGS; AGENTS;

D O I：

10.1134/S1070363223170097

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of new quinoline derivatives were designed, synthesized and evaluated for antiproliferative activity against two cancer cell lines (MCF-7 and HCCLM-3) and a human normal cell line (HEK293T cells). Among them, 3-(2,7-dimethoxyquinolin-3-yl)-1-(4-methoxyphenyl)prop-2-en-1-one displayed the most inhibitory activity against MCF-7 and HCCLM-3 cells, which were equal and better than the positive control 5-fluorouracil (82.18% vs. 83.29%, 94.79% vs. 76.98%), respectively. Additionally, it had poor inhibitory activity (48.14%) against HEK293T cells, which displayed good selectivity for cancer cells. Therefore, 3-(2,7-dimethoxyquinolin-3-yl)-1-(4-methoxyphenyl)prop-2-en-1-one could be as a lead compound to develop more potent anticancer agents.

引用

页码：S928 / S933

页数：6

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