COSMIC: a curated database of somatic variants and clinical data for cancer

被引：178

作者：

Sondka, Zbyslaw ^{[1
]}

Dhir, Nidhi Bindal ^{[1
]}

Carvalho-Silva, Denise ^{[1
]}

Jupe, Steven ^{[1
]}

Madhumita ^{[1
]}

Mclaren, Karen ^{[1
]}

Starkey, Mike ^{[1
]}

Ward, Sari ^{[1
]}

Wilding, Jennifer ^{[1
]}

Ahmed, Madiha ^{[1
]}

Argasinska, Joanna ^{[1
]}

Beare, David ^{[1
]}

Chawla, Manpreet Singh ^{[1
]}

Duke, Stephen ^{[1
]}

Fasanella, Ilaria ^{[1
]}

Neogi, Avirup Guha ^{[1
]}

Haller, Susan ^{[1
]}

Hetenyi, Balazs ^{[1
]}

Hodges, Leonie ^{[1
]}

Holmes, Alex ^{[1
]}

Lyne, Rachel ^{[1
]}

Maurel, Thomas ^{[1
]}

Nair, Sumodh ^{[1
]}

Pedro, Helder ^{[1
]}

Sangrador-Vegas, Amaia ^{[1
]}

Schuilenburg, Helen ^{[1
]}

Sheard, Zoe ^{[1
]}

Yong, Siew Yit ^{[1
]}

Teague, Jon ^{[1
]}

机构：

[1] Wellcome Sanger Inst, Wellcome Genome Campus, Hinxton CB10 1SA, Cambs, England

来源：

NUCLEIC ACIDS RESEARCH | 2023年 / 52卷 / D1期

关键词：

HALLMARKS; MUTATIONS;

D O I：

10.1093/nar/gkad986

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Catalogue Of Somatic Mutations In Cancer (COSMIC), https://cancer.sanger.ac.uk/cosmic, is an expert-curated knowledgebase providing data on somatic variants in cancer, supported by a comprehensive suite of tools for interpreting genomic data, discerning the impact of somatic alterations on disease, and facilitating translational research. The catalogue is accessed and used by thousands of cancer researchers and clinicians daily, allowing them to quickly access information from an immense pool of data curated from over 29 thousand scientific publications and large studies. Within the last 4 years, COSMIC has substantially expanded its utility by adding new resources: the Mutational Signatures catalogue, the Cancer Mutation Census, and Actionability. To improve data accessibility and interoperability, somatic variants have received stable genomic identifiers that are associated with their genomic coordinates in GRCh37 and GRCh38, and new export files with reduced data redundancy have been made available for download. [GRAPHICS] .

引用

页码：D1210 / D1217

页数：8

共 31 条

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