Metabolism in the tumor cell and beyond

被引：1

作者：

Carracedo, Arkaitz ^{[1
,2
,3
,4
,5
]}

机构：

[1] Basque Res & Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC BioGUNE, Bizkaia Technol Pk,Bldg 801A, Derio 48160, Spain

[2] CIBERONC, Madrid, Spain

[3] Ikerbasque, Basque Fdn Sci, Bilbao, Spain

[4] Biocruces Bizkaia Hlth Res Inst, Traslat Prostate Canc Res Lab, CIC BioGUNE Basurto, Bilbao, Spain

[5] Univ Basque Country, UPV EHU, Biochem & Mol Biol Dept, Bilbao, Spain

来源：

MOLECULAR ONCOLOGY | 2023年 / 17卷 / 06期

基金：

欧盟地平线“2020”; 欧洲研究理事会;

关键词：

anabolism; cancer metabolism; metabolic vulnerability; tumor microenvironment; ASPARTATE; RESPIRATION;

D O I：

10.1002/1878-0261.13467

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The process of cellular transformation encompasses the acquisition of key and distinctive features, commonly known as hallmarks of cancer. These hallmarks are supported by tumor-intrinsic molecular alterations, as well as changes in the microenvironment. Cellular metabolism represents one of the most intimate connections between a cell and the environment. In turn, metabolic adaptation is a research field of increasing interest in cancer biology. In this viewpoint, I will provide a panoramic perspective of the relevance and repercussions of metabolic alterations in tumors with nonexhaustive illustrative examples and I will speculate about the prospects of cancer metabolism research.

引用

页码：921 / 924

页数：4

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