Rejuvenation of Senescent Mesenchymal Stem Cells to Prevent Age-Related Changes in Synovial Joints

被引:3
作者
Sekelova, Tatiana [1 ,2 ]
Danisovic, Lubos [1 ,2 ]
Cehakova, Michaela [1 ,2 ,3 ]
机构
[1] Natl Inst Rheumat Dis, Piestany, Slovakia
[2] Comenius Univ, Inst Med Biol Genet & Clin Genet, Fac Med, Bratislava, Slovakia
[3] Natl Inst Rheumat Dis, Nabrezie I Krasku 4, Piestany 92112, Slovakia
关键词
senescence; senescent mesenchymal/medicinal stem/signaling cells; senescence-messaging secretome; aging joint; rejuvenation; INHIBITS OSTEOGENIC DIFFERENTIATION; DNA-DAMAGE RESPONSE; LONG-TERM CULTURE; BONE-MARROW; OXIDATIVE STRESS; EXTRACELLULAR VESICLES; CELLULAR SENESCENCE; MOLECULAR-WEIGHT; PREMATURE SENESCENCE; STROMAL CELLS;
D O I
10.1177/09636897231200065
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Mesenchymal/medicinal stem/signaling cells (MSCs), well known for regenerative potential, have been involved in hundreds of clinical trials. Even if equipped with reparative properties, aging significantly decreases their biological activity, representing a major challenge for MSC-based therapies. Age-related joint diseases, such as osteoarthritis, are associated with the accumulation of senescent cells, including synovial MSCs. An impaired ability of MSCs to self-renew and differentiate is one of the main contributors to the human aging process. Moreover, senescent MSCs (sMSCs) are characterized by the senescence-messaging secretome (SMS), which is typically manifested by the release of molecules with an adverse effect. Many factors, from genetic and metabolic pathways to environmental stressors, participate in the regulation of the senescent phenotype of MSCs. To better understand cellular senescence in MSCs, this review discusses the characteristics of sMSCs, their role in cartilage and synovial joint aging, and current rejuvenation approaches to delay/reverse age-related pathological changes, providing evidence from in vivo experiments as well.
引用
收藏
页数:17
相关论文
共 165 条
[1]   Hyaluronic Acid: Redefining Its Role [J].
Abatangelo, G. ;
Vindigni, V. ;
Avruscio, G. ;
Pandis, L. ;
Brun, P. .
CELLS, 2020, 9 (07) :1-19
[2]   A complex secretory program orchestrated by the inflammasome controls paracrine senescence [J].
Acosta, Juan Carlos ;
Banito, Ana ;
Wuestefeld, Torsten ;
Georgilis, Athena ;
Janich, Peggy ;
Morton, Jennifer P. ;
Athineos, Dimitris ;
Kang, Tae-Won ;
Lasitschka, Felix ;
Andrulis, Mindaugas ;
Pascual, Gloria ;
Morris, Kelly J. ;
Khan, Sadaf ;
Jin, Hong ;
Dharmalingam, Gopuraja ;
Snijders, Ambrosius P. ;
Carroll, Thomas ;
Capper, David ;
Pritchard, Catrin ;
Inman, Gareth J. ;
Longerich, Thomas ;
Sansom, Owen J. ;
Aznar Benitah, Salvador ;
Zender, Lars ;
Gil, Jesus .
NATURE CELL BIOLOGY, 2013, 15 (08) :978-U221
[3]   Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting [J].
Al-Azab, Mahmoud ;
Safi, Mohammed ;
Idiiatullina, Elina ;
Al-Shaebi, Fadhl ;
Zaky, Mohamed Y. .
CELLULAR & MOLECULAR BIOLOGY LETTERS, 2022, 27 (01)
[4]   Sublethal heat shock induces premature senescence rather than apoptosis in human mesenchymal stem cells [J].
Alekseenko, Larisa L. ;
Zemelko, Victoria I. ;
Domnina, Alisa P. ;
Lyublinskaya, Olga G. ;
Zenin, Valery V. ;
Pugovkina, Nataly A. ;
Kozhukharova, Irina V. ;
Borodkina, Alexandra V. ;
Grinchuk, Tatiana M. ;
Fridlyanskaya, Irina I. ;
Nikolsky, Nikolay N. .
CELL STRESS & CHAPERONES, 2014, 19 (03) :355-366
[5]   Mesenchymal Stromal Cell Proliferation, Gene Expression and Protein Production in Human Platelet-Rich Plasma-Supplemented Media [J].
Amable, Paola Romina ;
Telles Teixeira, Marcus Vinicius ;
Vieira Carias, Rosana Bizon ;
Granjeiro, Jose Mauro ;
Borojevic, Radovan .
PLOS ONE, 2014, 9 (08)
[6]   Recombinant HSP70 and mild heat shock stimulate growth of aged mesenchymal stem cells [J].
Andreeva, N. V. ;
Zatsepina, O. G. ;
Garbuz, D. G. ;
Evgen'ev, M. B. ;
Belyavsky, A. V. .
CELL STRESS & CHAPERONES, 2016, 21 (04) :727-733
[7]   Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles [J].
Arasu, Uma Thanigai ;
Karna, Riikka ;
Harkonen, Kai ;
Oikari, Sanna ;
Koistinen, Arto ;
Kroger, Heikki ;
Qu, Chengjuan ;
Lammi, Mikko J. ;
Rilla, Kirsi .
MATRIX BIOLOGY, 2017, 64 :54-68
[8]   Oral Administration of High Molecular Weight Hyaluronan (900 kDa) Controls Immune System via Toll-like Receptor 4 in the Intestinal Epithelium [J].
Asari, Akira ;
Kanemitsu, Tomoyuki ;
Kurihara, Hitoshi .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (32) :24751-24758
[9]   Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection [J].
Baddoo, M ;
Hill, K ;
Wilkinson, R ;
Gaupp, D ;
Hughes, C ;
Kopen, GC ;
Phinney, DG .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2003, 89 (06) :1235-1249
[10]   Bioactive molecules derived from umbilical cord mesenchymal stem cells [J].
Bai, Lipeng ;
Li, Danting ;
Li, Jie ;
Luo, Zhengzhong ;
Yu, Shumin ;
Cao, Suizhong ;
Shen, Liuhong ;
Zuo, Zhicai ;
Ma, Xiaoping .
ACTA HISTOCHEMICA, 2016, 118 (08) :761-769