Case Report: Response to ipilimumab and nivolumab in a patient with adrenocortical carcinoma

被引：1

作者：

Charles, Rebecca ^{[1
]}

Madhu, Divine ^{[2
]}

Powles, Alexander ^{[3
]}

Boyde, Adam ^{[1
]}

Hughes, Owen ^{[4
]}

Kumar, Nagappan ^{[5
]}

Moorcraft, Sing Yu ^{[6
,7
]}

机构：

[1] Univ Hosp Wales, Pathol Dept, Cardiff, Wales

[2] Cardiff Univ, Sch Med, Cardiff, Wales

[3] Swansea Bay Univ Hlth Board, Radiol Dept, Swansea, Wales

[4] Univ Hosp Wales, Dept Urol, Cardiff, Wales

[5] Univ Hosp Wales, Cardiff Liver Unit, Cardiff, Wales

[6] South West Wales Canc Ctr, Oncol Dept, Swansea, Wales

[7] Swansea Univ, Med Sch, Swansea, Wales

来源：

FRONTIERS IN ONCOLOGY | 2023年 / 13卷

关键词：

adrenocortical cancer; adrenal cancer; immunotherapy; ipilimumab; nivolumab; TUMORS;

D O I：

10.3389/fonc.2023.1242560

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundAdrenocortical carcinoma (ACC) is a rare malignancy with limited treatment options. The evidence for the use of immunotherapy in ACC has been conflicting, with overall response rates ranging from 6 - 33%.Case presentationWe describe the case of a 32 year old patient who was initially thought to have an inoperable clear cell renal cell carcinoma and was treated with immunotherapy with ipilimumab and nivolumab. The patient had an excellent partial response to treatment. Further work-up prior to consideration of surgery demonstrated that the tumour was an ACC, rather than a renal cancer. She had a right adrenalectomy and right hepatectomy, achieving an R0 resection and remains disease-free one year after surgery.ConclusionThis case illustrates the challenge of diagnosing ACC, and that doublet immunotherapy with ipilimumab and nivolumab can have significant clinical efficacy in ACC.

引用

页数：7

共 15 条

[1] PAX-8 expression in renal tumours and distant sites: A useful marker of primary and metastatic renal cell carcinoma? [J].

Barr, Meaghan L. ;

Jilaveanu, Lucia B. ;

Camp, Robert L. ;

Adeniran, Adebowale J. ;

Kluger, Harriet M. ;

Shuch, Brian .

JOURNAL OF CLINICAL PATHOLOGY, 2015, 68 (01) :12-17

[2] Nivolumab in Metastatic Adrenocortical Carcinoma: Results of a Phase 2 Trial [J].

Carneiro, Benedito A. ;

Konda, Bhavana ;

Costa, Rubens B. ;

Costa, Ricardo L. B. ;

Sagar, Vinay ;

Gursel, Demirkan B. ;

Kirschner, Lawrence S. ;

Chae, Young Kwang ;

Abdulkadir, Sarki A. ;

Rademaker, Alfred ;

Mahalingam, Devalingam ;

Shah, Manisha H. ;

Giles, Francis J. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2019, 104 (12) :6193-6200

[3] Adrenocortical carcinomas and malignant phaeochromocytomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up [J].

Fassnacht, M. ;

Assie, G. ;

Baudin, E. ;

Eisenhofer, G. ;

de la Fouchardiere, C. ;

Haak, H. R. ;

de Krijger, R. ;

Porpiglia, F. ;

Terzolo, M. ;

Berruti, A. .

ANNALS OF ONCOLOGY, 2020, 31 (11) :1476-1490

[4] Combination Chemotherapy in Advanced Adrenocortical Carcinoma [J].

Fassnacht, Martin ;

Terzolo, Massimo ;

Allolio, Bruno ;

Baudin, Eric ;

Haak, Harm ;

Berruti, Alfredo ;

Welin, Staffan ;

Schade-Brittinger, Carmen ;

Lacroix, Andre ;

Jarzab, Barbara ;

Sorbye, Halfdan ;

Torpy, David J. ;

Stepan, Vinzenz ;

Schteingart, David E. ;

Arlt, Wiebke ;

Kroiss, Matthias ;

Leboulleux, Sophie ;

Sperone, Paola ;

Sundin, Anders ;

Hermsen, Ilse ;

Hahner, Stefanie ;

Willenberg, Holger S. ;

Tabarin, Antoine ;

Quinkler, Marcus ;

de la Fouchardiere, Christelle ;

Schlumberger, Martin ;

Mantero, Franco ;

Weismann, Dirk ;

Beuschlein, Felix ;

Gelderblom, Hans ;

Wilmink, Hanneke ;

Sender, Monica ;

Edgerly, Maureen ;

Kenn, Werner ;

Fojo, Tito ;

Muller, Hans-Helge ;

Skogseid, Britt .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (23) :2189-2197

[5] Burden and centralised treatment in Europe of rare tumours: results of RARECAREnet-a population-based study [J].

Gatta, Gemma ;

Capocaccia, Riccardo ;

Botta, Laura ;

Mallone, Sandra ;

De Angelis, Roberta ;

Ardanaz, Eva ;

Comber, Harry ;

Dimitrova, Nadya ;

Leinonen, Maarit K. ;

Siesling, Sabine ;

van der Zwan, Jan M. ;

Van Eycken, Liesbet ;

Visser, Otto ;

Zakelj, Maja P. ;

Anderson, Lesley A. ;

Bella, Francesca ;

Innos, Kaire ;

Otter, Renee ;

Stiller, Charles A. ;

Trama, Annalisa .

LANCET ONCOLOGY, 2017, 18 (08) :1022-1039

[6] Phase II clinical trial of pembrolizumab efficacy and safety in advanced adrenocortical carcinoma [J].

Habra, Mouhammed Amir ;

Stephen, Bettzy ;

Campbell, Matthew ;

Hess, Kenneth ;

Tapia, Coya ;

Xu, Mingxuan ;

Ahnert, Jordi Rodon ;

Jimenez, Camilo ;

Lee, Jeffrey E. ;

Perrier, Nancy D. ;

Boraddus, Russell R. ;

Pant, Shubham ;

Subbiah, Vivek ;

Hong, David S. ;

Zarifa, Abdulrazzak ;

Fu, Siqing ;

Karp, Daniel D. ;

Meric-Bernstam, Funda ;

Naing, Aung .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7 (01)

[7] Response to Immunotherapy in Combination With Mitotane in Patients With Metastatic Adrenocortical Cancer [J].

Head, Lia ;

Kiseljak-Vassiliades, Katja ;

Clark, Toshimasa J. ;

Somerset, Hilary ;

King, Jonathan ;

Raeburn, Christopher ;

Albuja-Cruz, Maria ;

Weyant, Michael ;

Cleveland, Joseph ;

Wierman, Margaret E. ;

Leong, Stephen .

JOURNAL OF THE ENDOCRINE SOCIETY, 2019, 3 (12) :2295-2304

[8] Deficits in the Management of Patients With Adrenocortical Carcinoma in Germany [J].

Johanssen, Sarah ;

Hahner, Stefanie ;

Saeger, Wolfgang ;

Quinkler, Marcus ;

Beuschlein, Felix ;

Dralle, Henning ;

Haaf, Michaela ;

Kroiss, Matthias ;

Jurowich, Christian ;

Langer, Peter ;

Oelkers, Wolfgang ;

Spahn, Martin ;

Willenberg, Holger S. ;

Maeder, Uwe ;

Allolio, Bruno ;

Fassnacht, Martin .

DEUTSCHES ARZTEBLATT INTERNATIONAL, 2010, 107 (50) :885-U9

[9] Combination immunotherapy with ipilimumab and nivolumab in patients with advanced adrenocortical carcinoma: a subgroup analysis of CA209-538 [J].

Klein, Oliver ;

Senko, Clare ;

Carlino, Matteo S. ;

Markman, Ben ;

Jackett, Louise ;

Gao, Bo ;

Lum, Caroline ;

Kee, Damien ;

Behren, Andreas ;

Palmer, Jodie ;

Cebon, Jonathan .

ONCOIMMUNOLOGY, 2021, 10 (01)

[10] Avelumab in patients with previously treated metastatic adrenocortical carcinoma: phase 1b results from the JAVELIN solid tumor trial [J].

Le Tourneau, Christophe ;

Hoimes, Christopher ;

Zarwan, Corrine ;

Wong, Deborah J. ;

Bauer, Sebastian ;

Claus, Rainer ;

Wermke, Martin ;

Hariharan, Subramanian ;

von Heydebreck, Anja ;

Kasturi, Vijay ;

Chand, Vikram ;

Gulley, James L. .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2018, 6

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