Pulmonary hypertension in systemic sclerosis with usual interstitial pneumonia

被引：0

作者：

Carbone, Roberto G. ^{[1
]}

Monselise, Assaf ^{[2
]}

Barisione, Emanuela ^{[3
]}

Fontana, Vincenzo ^{[4
]}

Paredi, Paolo ^{[5
]}

Puppo, Francesco ^{[1
]}

机构：

[1] Univ Genoa, Dept Internal Med, Genoa, Italy

[2] Clalit Hlth Serv, Tel Aviv, Israel

[3] IRCCS San Martino Hosp, Intervent Pneumonol, Genoa, Italy

[4] IRCCS San Martino Hosp, Clin Epidemiol Unit, Genoa, Italy

[5] Natl Heart & Lung Inst, London, England

来源：

INTERNAL AND EMERGENCY MEDICINE | 2023年 / 18卷 / 04期

关键词：

Pulmonary hypertension; Systemic sclerosis; Interstitial lung disease; Idiopathic pulmonary fibrosis; Usual interstitial pneumonia; Non-specific interstitial pneumonia; LUNG-DISEASE; ARTERIAL-HYPERTENSION; CLINICAL CHARACTERISTICS; FIBROSIS; PREDICTORS; MORTALITY; SURVIVAL; IMPACT; RECOGNITION; DIAGNOSIS;

D O I：

10.1007/s11739-023-03267-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Retrospective study comparing pulmonary hypertension risk in systemic sclerosis (SSc) and non-SSc interstitial lung disease patients with usual interstitial pneumonia (UIP) and non-specific interstitial pneumonia (NSIP). Retrospective analysis of 144 interstitial lung disease patients, 53 SSc (32 UIP and 21 NSIP) and 91 non-SSc (47 UIP and 44 NSIP). Pulmonary hypertension was diagnosed as pulmonary systolic artery pressure (PAPs) > 25 mmHg. All SSc and non-SSc patients with pulmonary hypertension were classified WHO Group 3. Pulmonary hypertension was identified in 21/32 (65.6%), 9/21 (42.8%), 14/47 (29.7%), and 28/44 (45.4%) SSc-UIP, SSc-NSIP, control-UIP, and control-NSIP groups, respectively. PAPs mean of SSc-UIP group was higher than control-UIP group (32.6 +/- 9.8 vs 28.5 +/- 6.6, p-value = 0.02). PAPs mean of SSc-NSIP group was lower than control-NSIP group (27.0 +/- 7.1 vs 33.9 +/- 8.8, p = 0.002). Frequency of patients with PAP > 25 mmHg in SSc-UIP group was 60% higher in comparison to control-UIP (OR = 1.62, 95% CI 0.51-5.16) and SSc-NSIP (OR = 1.60, 95% CI 0.45-5.70) groups. Logistic regression analysis estimating the linear trend per ten-unit increase in PAPs levels demonstrated an increment for the SSc-UIP group compared to the control-UIP (OR = 2.64, 95% CI 1.25-5.58, p = 0.01) and the control-NSIP (OR = 6.34, 95% CI 2.82-14.3, p < 0.001) groups. The case-control study confirms that pulmonary hypertension is frequently found in SSc patients and demonstrates, for the first time, a significant increased risk of pulmonary hypertension among SSc-UIP patients.

引用

页码：1087 / 1093

页数：7

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