Development of a Water-Soluble Fluorescent Probe Based on Natural Flavylium for Mercury(II) Ion Detection and Clinical Antidote Evaluation

被引：12

作者：

Cheng, Xiang ^{[1
,2
]}

Feng, Bin ^{[1
,2
]}

Chen, Fei ^{[1
,2
]}

Huang, Shuai ^{[1
,2
]}

Zhang, Shengwang ^{[2
,3
]}

Gao, Feng ^{[2
,3
]}

Zeng, Wenbin ^{[1
,2
]}

机构：

[1] Cent South Univ, Xiangya Sch Pharmaceut Sci, Hunan Key Lab Diagnost & Therapeut Drug Res Chron, Changsha 410013, Peoples R China

[2] Cent South Univ, Mol Imaging Res Ctr, Changsha 410013, Peoples R China

[3] Cent South Univ, Xiangya Hosp 3, Changsha 410013, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2023年 / 71卷 / 36期

基金：

中国国家自然科学基金;

关键词：

natural flavylium; fluorescent probe; mercuryion pollution; environment detection; drug evaluation; STATE; ENVIRONMENT;

D O I：

10.1021/acs.jafc.3c04537

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The health hazard posed by Hg2+ makes it imperative to develop a fast and convenient means for detecting Hg2+ in water samples and living objects. While fluorescence sensing technology is considered a promising candidate, the poor water solubility and fluorescence quenching in aqueous solutions of most existing probes limit their practical application. To overcome this, we developed a natural flavylium-inspired fluorescent probe with excellent water solubility. Our probe demonstrated outstanding performance of high sensitivity (LOD = 0.47 nM), fast response (<10 min), and great selectivity for Hg2+. Notably, we validated its applicability in real water, urine samples, and living cells. Furthermore, the probe was successfully applied to evaluate the effectiveness of antidotes for clinical Hg2+ poisoning.

引用

页码：13263 / 13269

页数：7

共 47 条

[1] Sulfhydryl groups as targets of mercury toxicity [J].

Ajsuvakova, Olga P. ;

Tinkov, Alexey A. ;

Aschner, Michael ;

Rocha, Joao B. T. ;

Michalke, Bernhard ;

Skalnaya, Margarita G. ;

Skalny, Anatoly, V ;

Butnariu, Monica ;

Dadar, Maryam ;

Sarac, Ioan ;

Aaseth, Jan ;

Bjorklund, Geir .

COORDINATION CHEMISTRY REVIEWS, 2020, 417

[2] Insights on alpha lipoic and dihydrolipoic acids as promising scavengers of oxidative stress and possible chelators in mercury toxicology [J].

Bjorklund, Geir ;

Aaseth, Jan ;

Crisponi, Guido ;

Rahman, Md. Mostafizur ;

Chirumbolo, Salvatore .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2019, 195 :111-119

[3] Mercury in the marine environment of the Canadian Arctic: Review of recent findings [J].

Braune, Birgit ;

Chetelat, John ;

Amyot, Marc ;

Brown, Tanya ;

Clayden, Meredith ;

Evans, Marlene ;

Fisk, Aaron ;

Gaden, Ashley ;

Girard, Catherine ;

Hare, Alex ;

Kirk, Jane ;

Lehnherr, Igor ;

Letcher, Robert ;

Loseto, Lisa ;

Macdonald, Robie ;

Mann, Erin ;

McMeans, Bailey ;

Muir, Derek ;

O'Driscoll, Nelson ;

Poulain, Alexandre ;

Reimer, Ken ;

Stern, Gary .

SCIENCE OF THE TOTAL ENVIRONMENT, 2015, 509 :67-90

[4] The exquisite integration of ESIPT, PET and AIE for constructing fluorescent probe for Hg(II) detection and poisoning [J].

Cheng, Xiang ;

Huang, Shuai ;

Lei, Qian ;

Chen, Fei ;

Zheng, Fan ;

Zhong, Shibo ;

Huang, Xueyan ;

Feng, Bin ;

Feng, Xueping ;

Zeng, Wenbin .

CHINESE CHEMICAL LETTERS, 2022, 33 (04) :1861-1864

[5] Dichlororesorufin-Based Colorimetric and Fluorescent Probe for Ultrasensitive Detection of Mercury Ions in Living Cells and Zebrafish [J].

Duan, Qingxia ;

Lv, Xiaoyu ;

Liu, Caiyun ;

Geng, Zhuofan ;

Zhang, Fenfen ;

Sheng, Wenlong ;

Wang, Zuokai ;

Jia, Pan ;

Li, Zilu ;

Zhu, Hanchuang ;

Zhu, Baocun .

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2019, 58 (01) :11-17

[6] A carbonothioate-based far-red fluorescent probe for the specific detection of mercury ions in living cells and zebrafish [J].

Duan, Qingxia ;

Zhu, Hanchuang ;

Liu, Caiyun ;

Yuan, Ruifang ;

Fang, Zhaotong ;

Wang, Zuokai ;

Jia, Pan ;

Li, Zilu ;

Sheng, Wenlong ;

Zhu, Baocun .

ANALYST, 2019, 144 (04) :1426-1432

[7] Monitoring intracellular pH fluctuation with an excited-state intramolecular proton transfer-based ratiometric fluorescent sensor [J].

Feng, Bin ;

Zhu, Yingli ;

Wu, Jiaxin ;

Huang, Xueyan ;

Song, Rong ;

Huang, Liu ;

Feng, Xueping ;

Zeng, Wenbin .

CHINESE CHEMICAL LETTERS, 2021, 32 (10) :3057-3060

[8] Mercury consumption and human health: Linking pollution and social risk perception in the southeastern United States [J].

Ferreira-Rodriguez, Noe ;

Castro, Antonio J. ;

Tweedy, Beth N. ;

Quintas-Soriano, Cristina ;

Vaughn, Caryn C. .

JOURNAL OF ENVIRONMENTAL MANAGEMENT, 2021, 282

[9] Sensitive Water-Soluble Fluorescent Probe Based on Umpolung and Aggregation-Induced Emission Strategies for Selective Detection of Hg2+ in Living Cells and Zebrafish [J].

Gao, Tang ;

Huang, Xueyan ;

Huang, Shuai ;

Dong, Jie ;

Yuan, Kai ;

Feng, Xueping ;

Liu, Tingting ;

Yu, Kunqian ;

Zeng, Wenbin .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 67 (08) :2377-2383

[10] Revealing aggregation-induced emission effect of imidazolium derivatives and application for detection of Hg2+ [J].

Huang, Shuai ;

Gao, Tang ;

Bi, Anyao ;

Cao, Xiaozheng ;

Feng, Bin ;

Liu, Min ;

Du, Tao ;

Feng, Xueping ;

Zeng, Wenbin .

DYES AND PIGMENTS, 2020, 172

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