New Approved Drugs Appearing in the Pharmaceutical Market in 2022 Featuring Fragments of Tailor-Made Amino Acids and Fluorine

被引：25

作者：

Wang, Nana ^{[1
]}

Mei, Haibo ^{[1
]}

Dhawan, Gagan ^{[2
,3
,4
]}

Zhang, Wei ^{[5
]}

Han, Jianlin ^{[1
]}

Soloshonok, Vadim A. ^{[6
,7
]}

机构：

[1] Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Nanjing 210037, Peoples R China

[2] Delhi Skill & Entrepreneurship Univ, Sch Allied Med Sci, New Delhi 110075, India

[3] Univ Delhi, Acharya Narendra Dev Coll, Dept Biomed Sci, New Delhi 110019, India

[4] Univ Delhi, Inst Eminence, Delhi Sch Skill Enhancement & Entrepreneurship Dev, Delhi 110007, India

[5] Univ Massachusetts Boston, Dept Chem, 100 Morrissey Blvd, Boston, MA 02125 USA

[6] Univ Basque Country UPV EHU, Fac Chem, Dept Organ Chem 1, Paseo Manuel Lardizabal 3, San Sebastian 20018, Spain

[7] Basque Fdn Sci, IKERBASQUE, Alameda Urquijo 36 5, Bilbao 48011, Spain

来源：

MOLECULES | 2023年 / 28卷 / 09期

基金：

中国国家自然科学基金;

关键词：

fluorine-containing compounds; blockbuster drugs; pharmaceuticals; drug design and development; tailor-made amino acids; ASYMMETRIC-SYNTHESIS; HELICOBACTER-PYLORI; KINETIC RESOLUTION; PSMA INHIBITOR; TRIPLE THERAPY; VONOPRAZAN; DERIVATIVES; DISCOVERY; AGONIST; BLOCKER;

D O I：

10.3390/molecules28093651

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The strategic fluorination of oxidatively vulnerable sites in bioactive compounds is a relatively recent, widely used approach allowing us to modulate the stability, bio-absorption, and overall efficiency of pharmaceutical drugs. On the other hand, natural and tailor-made amino acids are traditionally used as basic scaffolds for the development of bioactive molecules. The main goal of this review article is to emphasize these general trends featured in recently approved pharmaceutical drugs.

引用

页数：21

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