Enhancing CD19 Chimeric Antigen Receptor T Cells Through Memory-Enriched T Cells

被引：4
作者：
El Marabti, Ettaib [1 ]
Abdel-Wahab, Omar [1 ,2 ,3 ]
机构：
[1] Sloan Kettering Inst, Mol Pharmacol Program, New York, NY USA
[2] Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY USA
[3] Sloan Kettering Inst, Memo rial Sloan Kettering Canc Ctr, Zuckerman Res Bldg, New York, NY 10065 USA
来源：
CLINICAL CANCER RESEARCH | 2023年 / 29卷 / 04期
关键词：
ACUTE LYMPHOBLASTIC-LEUKEMIA; BLINATUMOMAB; SURVIVAL; THERAPY; ADULTS;
D O I：
10.1158/1078-0432.CCR-22-3232
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chimeric antigen receptor T (CAR-T) cells directed against CD19 have transformed the therapy of relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL). A recent study reports promising activity and safety of CD19 CAR-T cells generated from naive, stem, and central memory T cells in adults with R/R B-ALL. See related article by Aldoss et al., p. 742 © 2023 American Association for Cancer Research Inc.. All rights reserved.
引用
收藏
页码：694 / 696
页数：3
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