Protein Phosphatase 2A Activation for the Treatment of Alzheimer Disease-Promises and Challenges

被引：2
作者：
Mondal, Prasenjit [1 ]
Samajdar, Saptarshi [1 ]
Acharyya, Suman [2 ]
Mondal, Sumanta [3 ]
机构：
[1] Brainware Univ, Dept Pharmaceut Technol, 328 Ramkrishnapur Rd, Kolkata 700126, W Bengal, India
[2] Netaji Subhas Chandra Bose Inst Pharm, Dept Pharmaceut Chem, Nadia, West Bengal, India
[3] GITAM Univ, GITAM Sch Pharm, Dept Pharmaceut Chem, Vishakhapatnam, Andhra Pradesh, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION | 2023年 / 13卷 / 04期
关键词：
Protein Phosphatase 2A; Alzheimer's disease; Tau phosphorylation; TAU PHOSPHORYLATION; CATALYTIC SUBUNITS; FINGOLIMOD FTY720; DOWN-SYNDROME; IN-VITRO; MEMANTINE; PP2A; EXPRESSION; MECHANISM; MODEL;
D O I：
10.5530/ijpi.13.4.089
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Alzheimer's disease is a progressive brain condition. It is characterized by alterations in the brain that result in the deposition of certain proteins. The brain shrinks and finally dies as a result of Alzheimer's disease. Over the years there has been very concerned efforts to control Alzheimer's disease with strategies like vaccinations but all off them failed in phase three trial. This leads to exploration of new strategy like activation of Protein Phosphatase 2A (PP2A) to control the tau phosphorylation in Alzheimer's. In this review, a comprehensive review regarding activation of PP2A using drugs like metformin, sphingosides, ceramides, folate and xylulose 5 phosphate, Sodium selenate, Adamantane derivatives, phenolic derivatives, Isoquinolones and Tetralones. Therefore, this approach can offer a fresh glimmer of hope for the treatment of Alzheimer's disease.
引用
收藏
页码：711 / 720
页数：10
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