Recent advances in shikonin for the treatment of immune-related diseases: Anti-inflammatory and immunomodulatory mechanisms

被引：25

作者：

Guo, Yimeng ^{[1
,2
,3
]}

Zhou, Mingming ^{[1
,2
,3
]}

Mu, Zhenzhen ^{[4
]}

Guo, Jinrong ^{[5
]}

Hou, Yuzhu ^{[1
,2
,3
]}

Xu, Yuanyuan ^{[1
,2
,3
]}

Geng, Long ^{[1
,2
,3
]}

机构：

[1] China Med Univ, Dept Dermatol, Hosp 1, 155N Nanjing St, Shenyang 110000, Liaoning, Peoples R China

[2] Natl joint Engn Res Ctr Theranost Immunol Skin Dis, Shenyang, Peoples R China

[3] Minist Educ & NHC, Key Lab Immunodermatol, Shenyang, Peoples R China

[4] China Med Univ, Dept Dermatol, Shengjing Hosp, 155N Nanjing St, Shenyang 110000, Liaoning, Peoples R China

[5] Jincheng Peoples Hosp, Dept Dermatol, 456N Wenchang East St, Jincheng 048000, Shanxi, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 165卷

关键词：

Traditional Chinese medicine; Shikonin; Anti-inflammation and immune regulation; Immune-associated inflammatory diseases; RHEUMATOID-ARTHRITIS; MULTIPLE-SCLEROSIS; MURINE MODEL; T-CELLS; B-CELLS; STAT3; TNF; INFLAMMATION; DERIVATIVES; EXPRESSION;

D O I：

10.1016/j.biopha.2023.115138

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Shikonin, the primary active compound found in the rhizome of the traditional Chinese medicinal herb known as "ZiCao", exhibits a diverse range of pharmacological effects. This drug has a wide range of uses, including as an anti-inflammatory, antioxidant, and anti-cancer agent. It is also effective in promoting wound healing and treating autoimmune diseases such as multiple sclerosis, diabetes, asthma, systemic lupus erythematosus, inflammatory bowel disease, psoriasis, and rheumatoid arthritis. Although shikonin has a wide range of applications, its mechanisms are still not fully understood. This review article provides a comprehensive overview of the recent advancements in the use of shikonin for the treatment of immune-related diseases. The article also delves into the anti-inflammatory and immunoregulatory mechanisms of shikonin and offers insights into the inflammation and immunopathogenesis of related diseases. Overall, this article serves as a valuable resource for researchers and clinicians working in this field. These findings not only provide significant new information on the effects and mechanisms of shikonin but also establish a foundation for the development of clinical applications in treating autoimmune diseases.

引用

页数：11

共 92 条

[91] Shikonin Controls the Differentiation of CD4+CD25+ Regulatory T Cells by Inhibiting AKT/mTOR Pathway [J].