Nanoliposomes for doxorubicin delivery: Reversing drug resistance, stimuli-responsive carriers and clinical translation

被引：21

作者：

Hashemi, Mehrdad ^{[1
,2
]}

Ghadyani, Fatemeh ^{[2
]}

Hasani, Sahar ^{[2
]}

Olyaee, Yeganeh ^{[2
]}

Raei, Behnaz ^{[2
]}

Khodadadi, Marzieh ^{[2
]}

Ziyarani, Maryam Fallah ^{[2
]}

Basti, Fatemeh A. ^{[2
,3
]}

Tavakolpournegari, Alireza ^{[4
]}

Matinahmadi, Arash ^{[5
]}

Salimimoghadam, Shokooh ^{[6
]}

Aref, Amir Reza ^{[7
,8
]}

Taheriazam, Afshin ^{[2
,9
]}

Entezari, Maliheh ^{[1
,2
]}

Ertas, Yavuz Nuri ^{[10
,11
]}

机构：

[1] Islamic Azad Univ, Fac Adv Sci & Technol, Dept Genet, Tehran Med Sci, Tehran, Iran

[2] Islamic Azad Univ, Farhikhtegan Hosp Tehran Med Sci, Farhikhtegan Med Convergence Sci Res Ctr, Tehran, Iran

[3] Islamic Azad Univ, Fac Med, Tehran Med Sci, Tehran, Iran

[4] Univ Autonoma Barcelona, Fac Biosci, Dept Genet & Microbiol, Grp Mutagenesis, Barcelona 08193, Spain

[5] Nicolaus Copernicus Univ, Biol & Vet Sci Fac, Dept Cellular & Mol Biol, Torun, Poland

[6] Shahid Chamran Univ Ahvaz, Fac Vet Med, Dept Biochem & Mol Biol, Ahvaz, Iran

[7] Harvard Med Sch, Dana Farber Canc Inst, Belfer Ctr Appl Canc Sci, Boston, MA USA

[8] Xsphera Biosci Inc, Translat Sci, 6 Tide St, Boston, MA 02210 USA

[9] Islamic Azad Univ, Fac Med, Dept Orthoped, Tehran Med Sci, Tehran, Iran

[10] Erciyes Univ, Dept Biomed Engn, Kayseri, Turkey

[11] Erciyes Univ, ERNAM Nanotechnol Res & Applicat Ctr, Kayseri, Turkey

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2023年 / 80卷

关键词：

Liposome; Doxorubicin; Cancer therapy; Chemoresistance; Co-delivery; PH-SENSITIVE LIPOSOMES; STERICALLY STABILIZED LIPOSOMES; CO-ENCAPSULATING DOXORUBICIN; CELL-PENETRATING PEPTIDE; MEDIATED INTRACELLULAR DELIVERY; IMPROVED ANTITUMOR EFFICACY; DUAL-EFFECT LIPOSOMES; LONG NONCODING RNAS; BREAST-CANCER; IN-VITRO;

D O I：

10.1016/j.jddst.2022.104112

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cancer is still a major threat to human life that is characterized by abnormal proliferation and metastasis of cancer cells. Chemotherapy is procedure of using anti-cancer drugs for preventing dissemination and prolifer-ation of tumor cells to kill them in improving survival rate and prognosis of patients. Chemotherapy has been a common conventional therapy for cancer, and it can be used along with surgical resection in cancer patients. However, drug resistance has led to chemotherapy failure in patients, especially in advanced and metastatic stages. Therefore, nano-scale delivery systems have been developed for reversing drug resistance and potenti-ating efficacy of chemotherapy agents. Liposomes are spherical vesicles with low particle size and high biocompatibility that have been used for drug delivery in cancer suppression. Liposomes can increase inter-nalization of doxorubicin (DOX) as an anti-cancer drug in tumor cells to boost its cytotoxicity. Furthermore, co -delivery of DOX with other anti-tumor drugs or gene therapy can lead to synergistic cancer therapy. pH-, redox-, light-and multi-sensitive liposomes have been designed for precise delivery of DOX in cancer suppression. Modification of liposomes with ligands such as hyaluronic acid that binds to CD44 receptor, enhances selectivity towards cancer cells. Furthermore, DOX-loaded liposomes mainly internalize in cancer cells via endocytosis that is dependent on different factors such as particle size, zeta potential and other physico-chemical properties.

引用

页数：20

共 345 条

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