Neuroinflammation in fetal alcohol spectrum disorders and related novel therapeutic approaches

被引：2

作者：

Padilla-Valdez, Mayra Madeleine ^{[1
,2
]}

Diaz-Iniguez, Maria Isabel ^{[1
,2
]}

Ortuno-Sahagun, Daniel ^{[2
]}

Rojas-Mayorquin, Argelia Esperanza ^{[1
]}

机构：

[1] Univ Guadalajara, Ctr Univ Ciencias Biol & Agr, Dept Ciencias Ambientales, Guadalajara 45200, Mexico

[2] Univ Guadalajara, Ctr Univ Ciencias Salud, Lab Neuroinmunobiol Mol, Inst Invest Ciencias Biomed IICB, Guadalajara 44340, Jal, Mexico

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2024年 / 1870卷 / 01期

关键词：

Neuroinflammation; FASD; Nutraceutical; Cannabidiol; Curcumin; Apelin-13; Omega-3; DHA SUPPLEMENTATION; OXIDATIVE STRESS; MOUSE MODEL; PREGNANCY; CYTOKINE; EXPOSURE; RISK; CELECOXIB; DIAGNOSIS; CHILDREN;

D O I：

10.1016/j.bbadis.2023.166854

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fetal alcohol spectrum disorders (FASD) is an umbrella term to describe the neurological effects of prenatal alcohol exposure (PAE). It has been extensively characterized that PAE causes cell proliferation disruption, heterotopias, and malformations in various brain regions and there is increasing evidence that neuro-inflammation is responsible for some of these neurotoxic effects. Despite evidence of its importance, neuroinflammation is not usually considered at diagnosis or treatment for FASD. Here, we discuss the literature regarding anti-inflammatory drugs and nutraceuticals, which hold promise for future therapeutical interventions in these disorders.

引用

页数：9

共 99 条

[1] Disentangling the Role of Astrocytes in Alcohol Use Disorder [J].

Adermark, Louise ;

Bowers, M. Scott .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2016, 40 (09) :1802-1816

[2] Epigallocatechin Gallate Ameliorates the Effects of Prenatal Alcohol Exposure in a Fetal Alcohol Spectrum Disorder-Like Mouse Model [J].

Almeida-Toledano, Laura ;

Andreu-Fernandez, Vicente ;

Aras-Lopez, Rosa ;

Garcia-Algar, Oscar ;

Martinez, Leopoldo ;

Gomez-Roig, Maria Dolores .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (02) :1-24

[3]

Ananchaipatana-Auitragoon P, 2015, EXCLI J, V14, P660, DOI 10.17179/excli2015-240

[4] Effects of lipoic acid on antiapoptotic genes in control and ethanol-treated fetal rhombencephalic neurons [J].

Antonio, Angeline M. ;

Gillespie, Roberta A. ;

Manteuffel, Mary J. Druse .

BRAIN RESEARCH, 2011, 1383 :13-21

[5] Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer's Disease Pathogenesis in a Transgenic Mouse Model [J].

Baranger, Kevin ;

Van Gijsel-Bonnello, Manuel ;

Stephan, Delphine ;

Carpentier, Wassila ;

Rivera, Santiago ;

Khrestchatisky, Michel ;

Gharib, Bouchra ;

De Reggi, Max ;

Benech, Philippe .

NEUROTHERAPEUTICS, 2019, 16 (04) :1237-1254

[6] Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro [J].

Barenys, Marta ;

Gassmann, Kathrin ;

Baksmeier, Christine ;

Heinz, Sabrina ;

Reverte, Ingrid ;

Schmuck, Martin ;

Temme, Thomas ;

Bendt, Farina ;

Zschauer, Tim-Christian ;

Rockel, Thomas Dino ;

Unfried, Klaus ;

Waetjen, Wim ;

Sundaram, Sivaraj Mohana ;

Heuer, Heike ;

Teresa Colomina, Maria ;

Fritsche, Ellen .

ARCHIVES OF TOXICOLOGY, 2017, 91 (02) :827-837

[7] Macrophage reprogramming for therapy [J].

Bart, Valentina M. T. ;

Pickering, Robert J. ;

Taylor, Philip R. ;

Ipseiz, Natacha .

IMMUNOLOGY, 2021, 163 (02) :128-144

[8] NUTRACEUTICALS IN 2017 Nutraceuticals in endocrine disorders [J].

Berberich, Amanda J. ;

Hegele, Robert A. .

NATURE REVIEWS ENDOCRINOLOGY, 2018, 14 (02) :69-70

[9] Immune network dysregulation associated with child neurodevelopmental delay: modulatory role of prenatal alcohol exposure [J].

Bodnar, Tamara S. ;

Raineki, Charlis ;

Wertelecki, Wladimir ;

Yevtushok, Lyubov ;

Plotka, Larisa ;

Granovska, Irina ;

Zymak-Zakutnya, Natalya ;

Pashtepa, Alla ;

Wells, Alan ;

Honerkamp-Smith, Gordon ;

Coles, Claire D. ;

Kable, Julie A. ;

Chambers, Christina D. ;

Weinberg, Joanne .

JOURNAL OF NEUROINFLAMMATION, 2020, 17 (01)

[10] Evidence for an immune signature of prenatal alcohol exposure in female rats [J].

Bodnar, Tamara S. ;

Hill, Lesley A. ;

Weinberg, Joanne .

BRAIN BEHAVIOR AND IMMUNITY, 2016, 58 :130-141

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