Healthy dietary patterns are associated with the gut microbiome in the Hispanic Community Health Study/Study of Latinos

被引：17

作者：

Peters, Brandilyn A. ^{[1
]}

Xing, Jiaqian ^{[1
]}

Chen, Guo-Chong ^{[1
]}

Usyk, Mykhaylo ^{[2
]}

Wang, Zheng ^{[1
]}

McClain, Amanda C. ^{[3
]}

Thyagarajan, Bharat ^{[4
]}

Daviglus, Martha L. ^{[5
]}

Sotres-Alvarez, Daniela ^{[6
]}

Hu, Frank B. ^{[7
]}

Knight, Rob ^{[8
,9
,10
,11
]}

Burk, Robert D. ^{[1
,12
,13
,14
]}

Kaplan, Robert C. ^{[1
,15
]}

Qi, Qibin ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY USA

[3] San Diego State Univ, Sch Exercise & Nutr Sci, San Diego, CA USA

[4] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN USA

[5] Univ Illinois, Inst Minor Hlth Res, Chicago, IL USA

[6] UNC Gillings Global Sch Publ Hlth, Dept Biostat, Chapel Hill, NC USA

[7] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[8] Univ Calif San Diego, Dept Pediat, La Jolla, CA USA

[9] Univ Calif San Diego, Dept Comp Sci & Engn, La Jolla, CA USA

[10] Univ Calif San Diego, Dept Bioengn, La Jolla, CA USA

[11] Univ Calif San Diego, Ctr Microbiome Innovat, La Jolla, CA USA

[12] Albert Einstein Coll Med, Dept Pediat, Bronx, NY USA

[13] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY USA

[14] Albert Einstein Coll Med, Dept Obstet & Gynecol & Womens Hlth, Bronx, NY USA

[15] Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, Seattle, WA USA

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2023年 / 117卷 / 03期

关键词：

gut microbiome; diet; Hispanic; Latino; cardiometabolic health; dietary pattern; Mediterranean diet; healthy eating index; CARDIOVASCULAR RISK-FACTORS; US HISPANICS/LATINOS; DIVERSE BACKGROUNDS; INDUCED OBESITY; DISEASE; PREVALENCE; METAANALYSIS; MECHANISMS; RESISTANCE; STABILITY;

D O I：

10.1016/j.ajcnut.2022.11.020

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Dietary patterns high in healthy minimally processed plant foods play an important role in modulating the gut microbiome and promoting cardiometabolic health. Little is known on the diet-gut microbiome relationship in US Hispanics/Latinos, who have a high burden of obesity and diabetes. Objective: In a cross-sectional analysis, we sought to examine the relationships of 3 healthy dietary patterns-the alternate Mediterranean diet (aMED), the Healthy Eating Index (HEI)-2015, and the healthful plant-based diet index (hPDI)-with the gut microbiome in US Hispanic/Latino adults, and to study the association of diet-related species with cardiometabolic traits. Methods: The Hispanic Community Health Study/Study of Latinos is a multi-site community-based cohort. At baseline (2008-2011), diet was assessed by using 2, 24-hour recalls. Shotgun sequencing was performed on stool samples collected in 2014-17 (n 1/4 2444). Analysis of Compositions of Microbiomes 2 (ANCOM2) was used to identify the associations of dietary pattern scores with gut microbiome species and functions, adjusting for sociodemographic, behavioral, and clinical covariates. Results: Better diet quality according to multiple healthy dietary patterns was associated with a higher abundance of species from class Clostridia, including [Eubacterium] eligens, Butyrivibrio crossotus, and Lachnospiraceae bacterium TF01-11, but functions related to better diet quality differed for the dietary patterns (e.g., aMED with pyruvate:ferredoxin oxidoreductase, hPDI with L-arabinose/lactose transport). Poorer diet quality was associated with a higher abundance of Acidaminococcus intestini and with functions of manganese/iron transport, adhesin protein transport, and nitrate reduction. Some healthy diet pattern-enriched Clostridia species were related to more favorable cardiometabolic traits such as lower triglycerides and waist-to-hip ratio. Conclusions: Healthy dietary patterns in this population are associated with a higher abundance of fiber-fermenting Clostridia species in the gut microbiome, consistent with previous studies in other racial/ethnic groups. Gut microbiota may be involved in the beneficial effect of higher diet quality on cardiometabolic disease risk.

引用

页码：540 / 552

页数：13