Gut Treg cells release IL-27 to regulate TH17 cell responses

被引：0
|
作者：
Lu, Li-Fan [1 ]
机构：
[1] Univ Calif San Diego, La Jolla, CA 92093 USA
来源：
NATURE IMMUNOLOGY | 2023年 / 24卷 / 12期
关键词：
D O I：
10.1038/s41590-023-01681-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interleukin-27 (IL-27) is a pleiotropic cytokine known for its diverse immune regulatory properties. Although innate immune cells are considered the major cellular sources of IL-27, we found that gut regulatory T cells (T-reg cells) secrete IL-27 under inflammatory conditions, allowing them to selectively limit intestinal helper T17 cell (T(H)17 cell) responses in various disease settings.
引用
收藏
页码：1980 / 1981
页数：2
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