Effect of dietary supplementation with Diuripres® on blood pressure, vascular health, and metabolic parameters in individuals with high-normal blood pressure or stage I hypertension: The CONDOR randomized clinical study

Our aim was to evaluate if a nutritional intervention with a dietary supplement (Diuripres & REG;) containing magnesium, standardized extract of orthosiphon, hawthorn, and hibiscus could positively affect blood pressure (BP), vascular health, and metabolic parameters in 60 individuals with high-normal BP or stage I hypertension. Participants followed a low-fat low-sodium Mediterranean diet for 4 weeks before being randomly allocated to 8-week treatment with two pills each day of either Diuripres & REG; or placebo. Diuripres & REG; significantly decreased systolic BP compared to placebo after 4 weeks (3.1 & PLUSMN; 0.8 mmHg; p < 0.05) and more consistently after 8 weeks (3.4 & PLUSMN; 0.9 mmHg; p < 0.05). At 8-week follow-up, after correction for multiple testing, dietary supplementation with Diuripres & REG; was associated with significant improvements in diastolic BP (-3.1 & PLUSMN; 0.6 mmHg; p < 0.05), aortic BP (-4.3 & PLUSMN; 0.4 mmHg; p < 0.05), and high-sensitivity C-reactive protein (hs-CRP; 0.04 & PLUSMN; 0.01 mg/dL; p < 0.05) in comparison with baseline. The reductions in diastolic BP (--3.8 & PLUSMN; 0.7 mmHg; p < 0.05), aortic BP (-5.2 & PLUSMN; 1.0 mmHg; p < 0.05), and hs-CRP (-0.03 & PLUSMN; 0.01 mg/dL; p < 0.05) were also significant compared to placebo. Therefore, our study shows that dietary supplementation with Diuripres & REG; may be useful in individuals with high-normal BP or stage I hypertension.