Photoinduced Cascade Difluoroalkylative Ring-Opening of Vinyl Cyclopropanes

被引：11

作者：

Chandu, Palasetty ^{[1
]}

Srinivasu, Vinjamuri ^{[1
]}

Gupta, Surbhi ^{[1
]}

Sureshkumar, Devarajulu ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res Kolkata, Dept Chem Sci, Mohanpur 741246, West Bengal, India

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 16期

关键词：

PHARMACEUTICALS; GENERATION;

D O I：

10.1021/acs.orglett.3c00820

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here, we report a facile and efficient method for the difluoroalkylation of vinyl cyclopropanes (VCPs) using visible light organophotoredox catalysis. This strategy exploits the interplay of alpha-amino alkyl radical-mediated halogen-atom transfer (XAT) reaction. The broad substrate scope, excellent functional group compatibility, operational simplicity, inexpensive CF2 precursors, and high efficiency make this protocol promising for the cost-efficient synthesis of allylic difluoroalkylated derivatives.

引用

页码：2857 / 2862

页数：6

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