Potential oxidoreductases inhibitors from medicinal plants-based phytochemicals: A review

被引：0

作者：

Gomes, Tarsila ^{[1
]}

Alejandro, Gracebio ^{[2
]}

Thao, Tran Thi Phuong ^{[3
,4
,6
]}

Vieira, Amandio Vincent ^{[1
,5
]}

机构：

[1] Simon Fraser Univ, Biomed Physiol & Kinesiol BPK, Burnaby, BC, Canada

[2] Univ Santo Tomas, Res Ctr Nat & Appl Sci, Thomas Aquinas Res Complex, Manila, Philippines

[3] Inst Chem, Vietnam Acad Sci & Technol VAST, Hanoi, Vietnam

[4] Grad Univ Sci & Technol, Vietnam Acad Sci & Technol VAST, Fac Chem, Hanoi, Vietnam

[5] Simon Fraser Univ, Res Lab BPK9625, Nutr & Metab, 8888 Univ Dr, Burnaby, BC, Canada

[6] Vietnam Acad Sci & Technol, Inst Chem, Cau Giay, 18 Hoang Quoc Viet Rd, Hanoi 10000, Vietnam

来源：

VIETNAM JOURNAL OF CHEMISTRY | 2024年 / 62卷 / 02期

关键词：

aldose reductase; diabetes; medicinal plants; oxidoreductases; sorbitol dehydrogenase; xanthine oxidoreductase; ALDOSE REDUCTASE INHIBITORS; XANTHINE-OXIDASE ACTIVITY; SERUM URIC-ACID; ALPHA-GLUCOSIDASE; CHEMICAL-CONSTITUENTS; OXIDATIVE STRESS; IN-VITRO; DIABETIC-NEPHROPATHY; PHENOLIC-COMPOUNDS; ETHANOLIC EXTRACT;

D O I：

10.1002/vjch.202300222

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Oxidoreductases (ORases) are enzymes that catalyze oxidation and reduction reactions in cells or extracellular compartments of the body. Genetic mutations and other factors that affect ORase activity have been implicated in a range of diseases, especially inherited metabolic disorders. Aldose reductase, sorbitol dehydrogenase, xanthine oxidoreductase are the ORases with relevance to diabetes pathology. Herein, the strategies for screening modulators of ORase activities, and medicinal plants whose phytochemicals have the potential to influence ORase activity, are described. The overall goal is to test and identify natural products and other compounds that may have a therapeutic benefit in relation to hyperglycemia and diabetes.

引用

页码：240 / 246

页数：7

共 79 条

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