Challenges and Prospects in Developing Future SARS-CoV-2 Vaccines: Overcoming Original Antigenic Sin and Inducing Broadly Neutralizing Antibodies

被引：7

作者：

Evans, John P. ^{[1
,2
,3
]}

Liu, Shan-Lu ^{[1
,2
,4
,5
]}

机构：

[1] Ohio State Univ, Ctr Retrovirus Res, Columbus, OH USA

[2] Ohio State Univ, Dept Vet Biosci, Columbus, OH USA

[3] Ohio State Univ, Mol Cellular & Dev Biol Program, Columbus, OH USA

[4] Ohio State Univ, Infect Dis Inst, Viruses & Emerging Pathogens Program, Columbus, OH USA

[5] Ohio State Univ, Dept Microbial Infect & Immun, Columbus, OH USA

来源：

JOURNAL OF IMMUNOLOGY | 2023年 / 211卷 / 10期

基金：

美国国家卫生研究院;

关键词：

BIVALENT; RESPONSES; BOOSTER; INFECTION; EVOLUTION;

D O I：

10.4049/jimmunol.2300315

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The impacts of the COVID-19 pandemic led to the development of several effective SARS-CoV-2 vaccines. However, waning vaccine efficacy as well as the antigenic drift of SARS-CoV-2 variants has diminished vaccine efficacy against SARS-CoV-2 infection and may threaten public health. Increasing interest has been given to the development of a next generation of SARS-CoV-2 vaccines with increased breadth and effectiveness against SARS-CoV-2 infection. In this Brief Review, we discuss recent work on the development of these next-generation vaccines and on the nature of the immune response to SARS-CoV-2. We examine recent work to develop pan-coronavirus vaccines as well as to developmucosal vaccines. We further discuss challenges associated with the development of novel vaccines including the need to overcome "original antigenic sin" and highlight areas requiring further investigation. We place this work in the context of SARS-CoV-2 evolution to inform how the implementation of future vaccine platforms may impact human health.

引用

页码：1459 / 1467

页数：9

共 103 条

[1] Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate [J].

Addetia, Amin ;

Crawford, Katharine H. D. ;

Dingens, Adam ;

Zhu, Haiying ;

Roychoudhury, Pavitra ;

Huang, Meei-Li ;

Jerome, Keith R. ;

Bloom, Jesse D. ;

Greninger, Alexander L. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2020, 58 (11)

[2]

Aguilar-Bretones Muriel, 2023, J Clin Invest, V133, DOI 10.1172/JCI162192

[3] Antibody Immunodominance: The Key to Understanding Influenza Virus Antigenic Drift [J].

Altman, Meghan O. ;

Angeletti, Davide ;

Yewdell, Jonathan W. .

VIRAL IMMUNOLOGY, 2018, 31 (02) :142-149

[4] SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinations [J].

Anderson, Elizabeth M. ;

Li, Shuk Hang ;

Awofolaju, Moses ;

Eilola, Theresa ;

Goodwin, Eileen ;

Bolton, Marcus J. ;

Gouma, Sigrid ;

Manzoni, Tomaz B. ;

Hicks, Philip ;

Goel, Rishi R. ;

Painter, Mark M. ;

Apostolidis, Sokratis A. ;

Mathew, Divij ;

Dunbar, Debora ;

Fiore, Danielle ;

Brock, Amanda ;

Weaver, JoEllen ;

Millar, John S. ;

DerOhannessian, Stephanie ;

Greenplate, Allison R. ;

Frank, Ian ;

Rader, Daniel J. ;

Wherry, E. John ;

Bates, Paul ;

Hensley, Scott E. .

CELL REPORTS, 2022, 41 (03)

[5] Immunological imprinting of the antibody response in COVID-19 patients [J].

Aydillo, Teresa ;

Rombauts, Alexander ;

Stadlbauer, Daniel ;

Aslam, Sadaf ;

Abelenda-Alonso, Gabriela ;

Escalera, Alba ;

Amanat, Fatima ;

Jiang, Kaijun ;

Krammer, Florian ;

Carratala, Jordi ;

Garcia-Sastre, Adolfo .

NATURE COMMUNICATIONS, 2021, 12 (01)

[6] A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection [J].

Beaudoin-Bussieres, Guillaume ;

Chen, Yaozong ;

Ullah, Irfan ;

Prevost, Jeremie ;

Tolbert, William D. ;

Symmes, Kelly ;

Ding, Shilei ;

Benlarbi, Mehdi ;

Gong, Shang Yu ;

Tauzin, Alexandra ;

Gasser, Romain ;

Chatterjee, Debashree ;

Vezina, Dani ;

Goyette, Guillaume ;

Richard, Jonathan ;

Zhou, Fei ;

Stamatatos, Leonidas ;

McGuire, Andrew T. ;

Charest, Hughes ;

Roger, Michel ;

Pozharski, Edwin ;

Kumar, Priti ;

Mothes, Walther ;

Uchil, Pradeep D. ;

Pazgier, Marzena ;

Finzi, Andres .

CELL REPORTS, 2022, 38 (07)

[7] Comparison of bivalent and monovalent SARS-CoV-2 variant vaccines: the phase 2 randomized open-label COVAIL trial [J].

Branche, Angela R. ;

Rouphael, Nadine G. ;

Diemert, David J. ;

Falsey, Ann R. ;

Losada, Cecilia ;

Baden, Lindsey R. ;

Frey, Sharon E. ;

Whitaker, Jennifer A. ;

Little, Susan J. ;

Anderson, Evan J. ;

Walter, Emmanuel B. ;

Novak, Richard M. ;

Rupp, Richard ;

Jackson, Lisa A. ;

Babu, Tara M. ;

Kottkamp, Angelica C. ;

Luetkemeyer, Anne F. ;

Immergluck, Lilly C. ;

Presti, Rachel M. ;

Baecker, Martin ;

Winokur, Patricia L. ;

Mahgoub, Siham M. ;

Goepfert, Paul A. ;

Fusco, Dahlene N. ;

Malkin, Elissa ;

Bethony, Jeffrey M. ;

Walsh, Edward E. ;

Graciaa, Daniel S. ;

Samaha, Hady ;

Sherman, Amy C. ;

Walsh, Stephen R. ;

Abate, Getahun ;

Oikonomopoulou, Zacharoula ;

El Sahly, Hana M. ;

Martin, Thomas C. S. ;

Kamidani, Satoshi ;

Smith, Michael J. ;

Ladner, Benjamin G. ;

Porterfield, Laura ;

Dunstan, Maya ;

Wald, Anna ;

Davis, Tamia ;

Atmar, Robert L. ;

Mulligan, Mark J. ;

Lyke, Kirsten E. ;

Posavad, Christine M. ;

Meagher, Megan A. ;

Stephens, David S. ;

Neuzil, Kathleen M. ;

Abebe, Kuleni .

NATURE MEDICINE, 2023, 29 (09) :2334-+

[8] Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution [J].

Cao, Yunlong ;

Jian, Fanchong ;

Wang, Jing ;

Yu, Yuanling ;

Song, Weiliang ;

Yisimayi, Ayijiang ;

Wang, Jing ;

An, Ran ;

Chen, Xiaosu ;

Zhang, Na ;

Wang, Yao ;

Wang, Peng ;

Zhao, Lijuan ;

Sun, Haiyan ;

Yu, Lingling ;

Yang, Sijie ;

Niu, Xiao ;

Xiao, Tianhe ;

Gu, Qingqing ;

Shao, Fei ;

Hao, Xiaohua ;

Xu, Yanli ;

Jin, Ronghua ;

Shen, Zhongyang ;

Wang, Youchun ;

Xie, Xiaoliang Sunney .

NATURE, 2023, 614 (7948) :521-+

[9] BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection [J].

Cao, Yunlong ;

Yisimayi, Ayijiang ;

Jian, Fanchong ;

Song, Weiliang ;

Xiao, Tianhe ;

Wang, Lei ;

Du, Shuo ;

Wang, Jing ;

Li, Qianqian ;

Chen, Xiaosu ;

Yu, Yuanling ;

Wang, Peng ;

Zhang, Zhiying ;

Liu, Pulan ;

An, Ran ;

Hao, Xiaohua ;

Wang, Yao ;

Feng, Rui ;

Sun, Haiyan ;

Zhao, Lijuan ;

Zhang, Wen ;

Zhao, Dong ;

Zheng, Jiang ;

Yu, Lingling ;

Li, Can ;

Zhang, Na ;

Wang, Rui ;

Niu, Xiao ;

Yang, Sijie ;

Song, Xuetao ;

Chai, Yangyang ;

Hu, Ye ;

Shi, Yansong ;

Zheng, Linlin ;

Li, Zhiqiang ;

Gu, Qingqing ;

Shao, Fei ;

Huang, Weijin ;

Jin, Ronghua ;

Shen, Zhongyang ;

Wang, Youchun ;

Wang, Xiangxi ;

Xiao, Junyu ;

Xie, Xiaoliang Sunney .

NATURE, 2022, 608 (7923) :593-+

[10] Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization [J].

Cele, Sandile ;

Jackson, Laurelle ;

Khoury, David S. ;

Khan, Khadija ;

Moyo-Gwete, Thandeka ;

Tegally, Houriiyah ;

San, James Emmanuel ;

Cromer, Deborah ;

Scheepers, Cathrine ;

Amoako, Daniel G. ;

Karim, Farina ;

Bernstein, Mallory ;

Lustig, Gila ;

Archary, Derseree ;

Smith, Muneerah ;

Ganga, Yashica ;

Jule, Zesuliwe ;

Reedoy, Kajal ;

Hwa, Shi-Hsia ;

Giandhari, Jennifer ;

Blackburn, Jonathan M. ;

Gosnell, Bernadett, I ;

Karim, Salim S. Abdool ;

Hanekom, Willem ;

von Gottberg, Anne ;

Bhiman, Jinal N. ;

Lessells, Richard J. ;

Moosa, Mahomed-Yunus S. ;

Davenport, Miles P. ;

de Oliveira, Tulio ;

Moore, Penny L. ;

Sigal, Alex .

NATURE, 2022, 602 (7898) :654-+

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